Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor. Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD. DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.
|Gene Name:||tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain|
|Family/Subfamily:||TNF Receptor , not assigned-TNF Receptor|
|Synonyms:||TNFRSF10D, CD264, Decoy receptors 2, DCR2, TRAILR4, TRAIL-R4, TRUNDD, CD264 antigen, Decoy receptor 2, TRAIL receptor 4|
|Target Sequences:||NM_003840 NP_003831.2 Q9UBN6|
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