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TRA2B / SFRS10

transformer 2 beta homolog (Drosophila)

Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.

Gene Name:	transformer 2 beta homolog (Drosophila)
Synonyms:	TRA2B, Htra2-beta, SRFS10, TRA2-BETA, TRAN2B, SFRS10, TRA-2 beta
Target Sequences:	NM_004593 NP_004584.1 P62995

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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