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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TPR

translocated promoter region, nuclear basket protein

Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:22253824 and PubMed:11952838). Plays also a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases.

Gene Name: translocated promoter region, nuclear basket protein
Synonyms: TPR, Translocated promoter region, Tumor potentiating region, Nucleoprotein TPR, Tpr-Met
Target Sequences: NM_003292 NP_003283.2 P12270

Filtered By: None
Target
TPR (19)
Reactivity
Human (19)
Mouse (9)
Rat (8)
Bat (4)
Bovine (11)
Chicken (5)
Chimpanzee (6)
Dog (12)
Gibbon (6)
Guinea pig (9)
Horse (9)
Monkey (9)
Pig (7)
Rabbit (12)
Application
IHC (6)
IHC-P (4)
WB (17)
ELISA (2)
ICC (2)
IF (2)
IP (4)
Peptide-ELISA (1)
Host
rabbit (18)
mouse (1)
Isotype
IgG (7)
IgG1,k (1)
Clonality
monoclonal mc (1)
polyclonal pc (18)
Clone
1A8 (1)
Format
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
Unconjugated (13)
Epitope
aa2034-2083 (4)
aa2276-2325 (4)
C-Terminus (3)
aa1650-1700 (1)
aa2026-2060 (1)
aa2275-2325 (1)
aa600-650 (1)
Publications
No (19)
Showing 1-19 of 19 results

TPR Antibody (C-Terminus) IHC-plus™ LS-B14268
Rabbit Polyclonal (IgG) to Human TPR
Rabbit, Mouse, Dog, Bovine, Pig, Human, Monkey
ICC IF IHC IHC-P
Unconjugated
50µl  $425.00
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Detection of Human TPR by Immunocytochemistry. Sample: NBF-fixed asynchronous HeLa cells. Antibody: Affinity purified rabbit anti-TPR used at a dilution of 1:250. Detection: anti-rabbit IgG-FITC conjugated used at a dilution of 1:100.
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Detection of Human TPR by Immunocytochemistry. Sample: NBF-fixed asynchronous HeLa cells. Antibody: Affinity purified rabbit anti-TPR used at a dilution of 1:250. Detection: anti-rabbit IgG-FITC conjugated used at a dilution of 1:100.

TPR Antibody (aa1650-1700) IHC-plus™ LS-B13990
Rabbit Polyclonal (IgG) to Human TPR
Chicken, Rabbit, Mouse, Dog, Rat, Horse, Human
IHC IHC-P IP WB
Unconjugated
50µl 0.2mg/ml  $425.00
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

TPR Antibody (aa2276-2325) LS-C135922
Rabbit Polyclonal to Human TPR
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
50µg  $365.00
TPR antibody Western blot of Fetal Lung lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
TPR antibody Western blot of Fetal Lung lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

TPR Antibody (aa2276-2325, HRP) LS-C468265
Rabbit Polyclonal to Human TPR
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
TPR antibody Western blot of Fetal Lung lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
TPR antibody Western blot of Fetal Lung lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

TPR Antibody (aa2276-2325, Biotin) LS-C468263
Rabbit Polyclonal to Human TPR
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
TPR antibody Western blot of Fetal Lung lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
TPR antibody Western blot of Fetal Lung lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

TPR Antibody (aa2276-2325, FITC) LS-C468264
Rabbit Polyclonal to Human TPR
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
WB
FITC Conjugated
100µl 1mg/ml  $385.00
TPR antibody Western blot of Fetal Lung lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
TPR antibody Western blot of Fetal Lung lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

TPR Antibody (C-Terminus) LS-C287677
Rabbit Polyclonal (IgG) to Human TPR
Rabbit, Dog, Bovine, Pig, Human
ICC IF IHC IHC-P IP WB
Unconjugated
100µl 0.2mg/ml  $395.00
Detection of Human TPR by Immunohistochemistry. Sample: FFPE section of human testis. Antibody: Affinity purified rabbit anti-TPR used at a dilution of 1:100 (2 ug/ml). Detection: DAB.
Detection of Human TPR by Immunohistochemistry. Sample: FFPE section of human testis. Antibody: Affinity purified rabbit anti-TPR used at a dilution of 1:100 (2 ug/ml). Detection: DAB.

TPR Antibody (clone 1A8) LS-C133494
Mouse Monoclonal [clone 1A8] (IgG1,k) to Human TPR
Human
ELISA IHC IHC-P WB
Unconjugated
100µg 0.41mg/ml  $355.00
Immunoperoxidase of monoclonal antibody to TPR on formalin-fixed paraffin-embedded human cerebellum. [antibody concentration 3 ug/ml]
Detection limit for recombinant GST tagged TPR is approximately 0.1 ng/ml as a capture antibody.
Immunoperoxidase of monoclonal antibody to TPR on formalin-fixed paraffin-embedded human cerebellum. [antibody concentration 3 ug/ml]
Detection limit for recombinant GST tagged TPR is approximately 0.1 ng/ml as a capture antibody.

TPR Antibody (C-Terminus) LS-C145072
Rabbit Polyclonal to Human TPR
Human
IHC WB
Unconjugated
100µl  $365.00

TPR Antibody LS-C406630
Rabbit Polyclonal (IgG) to Human TPR
Mouse, Rat, Human
ELISA IHC
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human breast cancer using TPR Polyclonal Antibody at dilution of 1:20.
Immunohistochemistry of Human breast cancer using TPR Polyclonal Antibody at dilution of 1:20.

TPR Antibody (aa600-650) LS-C286025
Rabbit Polyclonal (IgG) to Human TPR
Human
IP WB
Unconjugated
100µl 0.2mg/ml  $395.00

TPR Antibody (aa2275-2325) LS-C287678
Rabbit Polyclonal (IgG) to Human TPR
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Human
IP WB
Unconjugated
100µl 0.2mg/ml  $395.00

TPR Antibody (aa2026-2060) LS-C392644
Rabbit Polyclonal to Human TPR
Human
Peptide-ELISA WB
Unconjugated
80µl  $205.00; 400µl  $305.00
Anti-TPR Antibody (C-term)at 1:2000 dilution + HeLa whole cell lysates Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 267 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
Anti-TPR Antibody (C-term)at 1:2000 dilution + HeLa whole cell lysates Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 267 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.

TPR Antibody LS-C756421
Rabbit Polyclonal (IgG) to Human TPR
Mouse, Rat, Human
WB
Unconjugated
100µg  $325.00

TPR Antibody LS-C48703
Rabbit Polyclonal to Human TPR
Human
WB
Unconjugated
100µl  $405.00

TPR Antibody (aa2034-2083) LS-C135923
Rabbit Polyclonal to Human TPR
Chicken, Bovine, Rabbit, Dog, Guinea pig, Horse, Human, Monkey
WB
Unconjugated
50µg  $365.00
TPR antibody Western blot of 721_B Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
TPR antibody Western blot of 721_B Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

TPR Antibody (aa2034-2083, HRP) LS-C468268
Rabbit Polyclonal to Human TPR
Chicken, Bovine, Rabbit, Dog, Guinea pig, Horse, Gibbon, Human, Monkey, Chimpanzee
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
TPR antibody Western blot of 721_B Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
TPR antibody Western blot of 721_B Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

TPR Antibody (aa2034-2083, Biotin) LS-C468266
Rabbit Polyclonal to Human TPR
Chicken, Bovine, Rabbit, Dog, Guinea pig, Horse, Gibbon, Human, Monkey, Chimpanzee
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
TPR antibody Western blot of 721_B Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
TPR antibody Western blot of 721_B Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

TPR Antibody (aa2034-2083, FITC) LS-C468267
Rabbit Polyclonal to Human TPR
Chicken, Bovine, Rabbit, Dog, Guinea pig, Horse, Gibbon, Human, Monkey, Chimpanzee
WB
FITC Conjugated
100µl 1mg/ml  $385.00
TPR antibody Western blot of 721_B Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
TPR antibody Western blot of 721_B Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Showing 1-19 of 19 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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