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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TPMT

thiopurine S-methyltransferase

TPMT is the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.

Gene Name: thiopurine S-methyltransferase
Synonyms: TPMT, Thiopurine S-methyltransferase, Thiopurine methyltransferase
Target Sequences: NM_000367 NP_000358.1 P51580

Filtered by: None
Type
Over-Expression Lysate (2)
Recombinant (6)
Target
TPMT (8)
Tag
GST (2)
His + T7 (1)
Myc + DDK (3)
Species
Human (7)
Source
293T Cells (1)
E. coli (4)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purification
Purified (3)
Low Endotoxin Level
Low endotoxin level (1)
Publications
No (8)
Showing 1-8 of 8 results

Human TPMT Protein (Recombinant GST) (aa4-244) - LS-G22064
E. coli
GST
55.1 kD
1000µg  $1,245.00; 500µg  $785.00; 200µg  $475.00; 50µg  $275.00; 10µg  $235.00; 100µg  $355.00

Human TPMT Protein (Recombinant His + T7) (aa26-227) - LS-G25118
E. coli
His + T7
26.9 kDa
10µg  $275.00; 50µg  $455.00; 100µg  $605.00; 200µg  $875.00; 1mg  $2,265.00; 500µg  $1,005.00
Recombinant Thiopurine Methyltransferase By SDS-PAGE

Human TPMT Protein (Recombinant) - LS-G3580
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
100µg 1mg/ml  $365.00; 0.5mg 1mg/ml  $935.00
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image

Human TPMT Protein (Recombinant GST) (Full Length) - LS-G30762
Wheat Germ Extract
GST
52.69 kDa
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE of human TPMT stained with Coomassie Blue

Human TPMT Protein (Recombinant) - LS-G18474
E. coli
None
5µg  $195.00; 20µg  $255.00; 1mg  $3,780.00

Human TPMT Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G79136
293T Cells
Myc + DDK
28 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human TPMT Protein (Recombinant Myc + DDK) (Full Length) - LS-G67104
HEK 293 Cells
Myc + DDK
28 kDa
20µg  $890.00
Purified recombinant protein TPMT was analyzed by SDS-PAGE gel and Coomassie Blue Staining

TPMT Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G99016
HEK 293 Cells
Myc + DDK
28 kDa
100µg  $365.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Showing 1-8 of 8 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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