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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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TPM3
Tropomyosin 3
TPM3 is a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants.
| Gene Name: | Tropomyosin 3 |
| Synonyms: | TPM3, CFTD, Cytoskeletal tropomyosin TM30, Gamma-tropomyosin, NEM1, Hscp30, TM30nm, Tropomyosin alpha-3 chain, TM-5, TM5, TPMsk3, Tropomyosin 3, Tropomyosin-5, TM3, TM30, TRK, Tropomyosin-3, HTM5, OK/SW-cl.5, Tropomyosin gamma |
| Target Sequences: | NM_152263 NP_689476.2 P06753 |
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