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TPM3

Tropomyosin 3

TPM3 is a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants.

Gene Name: Tropomyosin 3
Synonyms: TPM3, CFTD, Cytoskeletal tropomyosin TM30, Gamma-tropomyosin, NEM1, Hscp30, TM30nm, Tropomyosin alpha-3 chain, TM-5, TM5, TPMsk3, Tropomyosin 3, Tropomyosin-5, TM3, TM30, TRK, Tropomyosin-3, HTM5, OK/SW-cl.5, Tropomyosin gamma
Target Sequences: NM_152263 NP_689476.2 P06753

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Products
Antibodies (35)
Primary (35)
TPM3 (35)
Human (26)
Mouse (19)
Rat (7)
Bat (3)
Bovine (3)
Chicken (3)
Chimpanzee (3)
Dog (3)
Gibbon (3)
Guinea pig (3)
Horse (3)
Monkey (3)
Orangutan (3)
Pig (3)
Rabbit (3)
Sheep (3)
Xenopus (3)
Zebrafish (3)
IHC (9)
IHC-P (3)
WB (31)
ELISA (8)
ICC (1)
IF (5)
Peptide-ELISA (1)
rabbit (33)
mouse (2)
Product Group
IHCPlus (3)
IgG (15)
IgG1,k (1)
IgG2a,k (1)
monoclonal mc (2)
polyclonal pc (33)
1649CT306.29.13 (1)
2E4 (1)
APC (2)
APC Conjugated (2)
Biotin Conjugated (4)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (2)
Unconjugated (15)
aa1-285 (8)
aa6-248 (8)
aa143-192 (4)
No (35)
TPM3 Antibody - Anti-TPM3 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 20 ug/ml.
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TPM3 Mouse anti-Human Monoclonal (2E4) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
TPM3 Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TPM3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC-P, WB
Unconjugated
50 µl/$460
TPM3 Antibody - TPM3 antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TPM3 Rabbit anti-Human Polyclonal (aa143-192) Antibody
Human
WB
Unconjugated
100 µl/$424
TPM3 Antibody - Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TPM3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
TPM3 Antibody - 1:100 staining human prostate tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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TPM3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
TPM3 Antibody - Immunohistochemistry of paraffin-embedded human liver cancer using TPM3 Antibody at dilution of 1:100
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TPM3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
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TPM3 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
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TPM3 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
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TPM3 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
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TPM3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
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TPM3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
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TPM3 Rabbit anti-Mouse Polyclonal Antibody
Mouse
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
TPM3 Antibody - Western blot of TPM3 pAb in extracts from 293T and A431 cells.
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TPM3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
TPM3 Antibody - Immunofluorescence analysis of HeLa cells using TPM3 Polyclonal Antibody.
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TPM3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
TPM3 Antibody - Immunohistochemistry of paraffin-embedded mouse heart using TPM3 antibody at dilution of 1:100 (40x lens).
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TPM3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
TPM3 Antibody - All lanes: Anti-TPM3 Antibody at 1:2000 dilution Lane 1: Hela whole cell lysate Lane 2: NIH/3T3 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size: 33 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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TPM3 Mouse anti-Human Monoclonal (1649CT306.29.13) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$393
TPM3 Antibody - Western blot of TPM3 antibody.
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TPM3 Rabbit anti-Mouse Polyclonal (aa6-248) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
TPM3 Antibody - Western blot of TPM3 antibody.
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TPM3 Rabbit anti-Mouse Polyclonal (aa6-248) (HRP) Antibody
Mouse
WB
HRP Conjugated
100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722; 2 ml/$959; 5 ml/$1,639
TPM3 Antibody - Western blot of TPM3 antibody.
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TPM3 Rabbit anti-Mouse Polyclonal (aa6-248) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387
TPM3 Antibody - Western blot of TPM3 antibody.
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TPM3 Rabbit anti-Mouse Polyclonal (aa6-248) (FITC) Antibody
Mouse
WB
FITC Conjugated
100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765
TPM3 Antibody - Western blot of TPM3 antibody.
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TPM3 Rabbit anti-Mouse Polyclonal (aa6-248) (APC) Antibody
Mouse
WB
APC Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
TPM3 Antibody - Western blot of TPM3 antibody.
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TPM3 Rabbit anti-Mouse Polyclonal (aa6-248) (APC, Cy7) Antibody
Mouse
WB
APC, Cy7 Conjugated
100 µl/$513; 200 µl/$666; 500 µl/$1,175; 1 ml/$1,441; 2 ml/$2,017; 5 ml/$3,781
TPM3 Antibody - Western blot of TPM3 antibody.
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TPM3 Rabbit anti-Mouse Polyclonal (aa6-248) (Cy3) Antibody
Mouse
WB
Cy3 Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
TPM3 Antibody - Western blot of TPM3 antibody.
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TPM3 Rabbit anti-Mouse Polyclonal (aa6-248) (PE) Antibody
Mouse
WB
PE Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
TPM3 Antibody - Western blot of TPM3 antibody.
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TPM3 Rabbit anti-Human Polyclonal (aa1-285) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).