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TPM1 / Tropomyosin

tropomyosin 1 (alpha)

TPM1 / Tropomyosin is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.

Gene Name: tropomyosin 1 (alpha)
Synonyms: TPM1, Alpha-tropomyosin, C15orf13, Cardiomyopathy, hypertrophic 3, CMD1Y, CMH3, HTM-alpha, Sarcomeric tropomyosin kappa, TMSA, Tropomyosin, Tropomyosin 1 (alpha), Tropomyosin alpha-1 chain, Tropomyosin-1
Target Sequences: NM_000366 NP_000357.3 P09493

Publications (2)

1
Transcriptomic Profiling of the Liver Sinusoidal Endothelium during Cirrhosis Reveals Stage-Specific Secretory Signature. Nicolò Manicardi, Anabel Fernández-Iglesias, Laia Abad-Jordà, Felix Royo, Mikel Azkargorta, Martí Ortega-Ribera, David Sanfeliu-Redondo, Ana Martínez-Alcocer, Felix Elortza, Amelia J Hessheimer, Constantino Fondevila, Juan José Lozano, Juan Carlos García-Pagán, Jaime Bosch, Francisco Javier Cubero, Agustín Albillos, Javier Vaquero, Juan M Falcón-Pérez, Jordi Gracia-Sancho. Cancers. 2021 May;13: [Full Text Article] [PubMed:34072510] [PMC:PMC8198220]
2
Differential glomerular proteome analysis of two murine nephropathy models at onset of albuminuria. Blutke A, Block C, Berendt F, Herbach N, Kemter E, Amann K, Fr[Character f6]hlich T, Arnold GJ, Wanke R. Proteomics. Clinical applications. 2011 Jun;5:375-81. [Full Text Article] [PubMed:21538912] Related Antibodies: LS-C31829.

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Proteins (25)
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TPM1 / Tropomyosin (25)
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10His, N-terminus + Myc, C-terminus (2)
6His, N-terminus + Myc, C-terminus (1)
6His-SUMO, N-terminus (1)
GST (1)
GST, N-terminus (1)
His (1)
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Dermatophagoides farinae (1)
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293T Cells (6)
Baculovirus (1)
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HEK 293 Cells (12)
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Purified (6)
TPM1 / Tropomyosin Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
TPM1 / Tropomyosin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
32.7 kDa
100 µg/$494
TPM1 / Tropomyosin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
32.6 kDa
100 µg/$494
TPM1 / Tropomyosin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
32.7 kDa
100 µg/$494
TPM1 / Tropomyosin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
32.5 kDa
100 µg/$494
TPM1 / Tropomyosin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
32.5 kDa
100 µg/$494
TPM1 / Tropomyosin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
32.6 kDa
100 µg/$494
TPM1 / Tropomyosin Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
49.0kDa
1 mg/$1,679; 100 µg/$598; 20 µg/$405
TPM1 / Tropomyosin Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus + Myc, C-terminus
36.2 kDa
100 µg/$679; 20 µg/$429; 1 mg/$1,973
TPM1 / Tropomyosin Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Baculovirus
10His, N-terminus + Myc, C-terminus
36.7 kDa
100 µg/$1,164; 20 µg/$475; 1 mg/$2,187
TPM1 / Tropomyosin Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
10His, N-terminus + Myc, C-terminus
37.7 kDa
20 µg/$405; 1 mg/$1,679; 100 µg/$598
TPM1 / Tropomyosin Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
TPM1 / Tropomyosin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
32.6 kDa
20 µg/$150
TPM1 / Tropomyosin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
32.5 kDa
20 µg/$150
TPM1 / Tropomyosin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
32.7 kDa
20 µg/$150
TPM1 / Tropomyosin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
32.6 kDa
20 µg/$150
Select
293T Cells
Myc-DDK (Flag)
32.7 kDa
20 µg/$150
TPM1 / Tropomyosin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
32.5 kDa
20 µg/$150
TPM1 / Tropomyosin Protein - 12.5% SDS-PAGE of human TPM1 stained with Coomassie Blue
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Wheat Germ Extract
GST
54.8 kDa
10 µg/$479; 25 µg/$670
TPM1 / Tropomyosin Protein - Purified recombinant protein TPM1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
32.5 kDa
20 µg/$1,107
TPM1 / Tropomyosin Protein - Purified recombinant protein TPM1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
32.5 kDa
20 µg/$1,107
TPM1 / Tropomyosin Protein - Purified recombinant protein TPM1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
32.7 kDa
20 µg/$1,107
TPM1 / Tropomyosin Protein - Purified recombinant protein TPM1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
32.7 kDa
20 µg/$1,107
TPM1 / Tropomyosin Protein - Purified recombinant protein TPM1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
32.6 kDa
20 µg/$1,107
TPM1 / Tropomyosin Protein - Purified recombinant protein TPM1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
32.6 kDa
20 µg/$1,107
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).