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TPH2

tryptophan hydroxylase 2

TPH2 encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.

Gene Name: tryptophan hydroxylase 2
Synonyms: TPH2, ADHD7, NTPH, Tryptophan hydroxylase 2, Tryptophan 5-hydroxylase 2, Tryptophan 5-monooxygenase 2
Target Sequences: NM_173353 NP_775489.2 Q8IWU9

Publications (1)

1
Activation of glucagon-like peptide-1 receptors reduces the acquisition of aggression-like behaviors in male mice. Jesper Vestlund, Qian Zhang, Olesya T Shevchouk, Daniel Hovey, Lundström Sebastian, Lars Westberg, Elisabet Jerlhag. Translational psychiatry. 2022 October;12:445. [Full Text Article] [PubMed:36229445] [PMC:PMC9561171] Related Antibodies: LS-C346253.

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Proteins (5)
Recombinant (5)
TPH2 (5)
No (5)
6His, N-terminus (3)
His-GST (1)
Myc-DDK (Flag) (1)
Human (4)
Mouse (1)
E. coli (4)
HEK 293 Cells (1)
Purified (1)
Low endotoxin level (2)
TPH2 Protein - Recombinant Tryptophan Hydroxylase 2 By SDS-PAGE
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E. coli
His-GST
45.6 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
TPH2 Protein - Purified recombinant protein TPH2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
55.9 kDa
20 µg/$1,107
TPH2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His, N-terminus
100 µg/$1,128; 20 µg/$721
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
58.8 kDa
10 µg/$344; 50 µg/$584
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
58.8kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).