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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TPH1 / Tryptophan Hydroxylase

tryptophan hydroxylase 1

TPH1 / TPH encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.

Gene Name: tryptophan hydroxylase 1
Family/Subfamily: Monooxygenase
Synonyms: TPH1, L-tryptophan hydroxylase, TRPH, Tryptophan 5-hydroxylase 1, Tryptophan 5-monooxygenase 1, TPRH, Tryptophan hydroxylase 1, TPH
Target Sequences: NM_004179 NP_004170.1 P17752

Publications (1)

1
Serotonin transporter antagonists target tumor-initiating cells in a transgenic mouse model of breast cancer. Hallett RM, Girgis-Gabardo A, Gwynne WD, Giacomelli AO, Bisson JN, Jensen JE, Dvorkin-Gheva A, Hassell JA. Oncotarget. 2016 7:53137-53152. (WB; Human) [Full Text Article] [PubMed:27447971] [PMC:PMC5288174] Related Antibodies: LS-C117936.

Filtered by: None
Target
TPH1 / Tryptophan Hydroxylase (55)
Reactivity
Human (49)
Mouse (26)
Rat (26)
Bovine (2)
Chicken (2)
Dog (1)
Mammal (1)
Rabbit (9)
Xenopus (2)
Application
IHC (23)
IHC-Fr (2)
IHC-P (12)
WB (42)
Flo (1)
ELISA (27)
ICC (5)
IF (12)
IP (3)
Peptide-ELISA (4)
Host
rabbit (48)
mouse (5)
sheep (2)
Isotype
IgG (31)
IgG3 (4)
Clonality
monoclonal mc (5)
polyclonal pc (50)
Clone
F12 3C8 (1)
Try-63 (3)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (4)
HRP Conjugated (3)
Magnetic beads Conjugated (1)
PE Conjugated (1)
Sepharose Conjugated (1)
Unconjugated (40)
Epitope
aa35-62 (8)
pSer58 (4)
200-280 aa (2)
40-120 aa (2)
Internal (1)
Lys54 (1)
N-Terminus (1)
Ser260 (1)
Ser31 (1)
Ser40 (1)
Val256 (1)
aa231-280 (1)
aa26-75 (1)
pSer19 (1)
pSer260 (1)
Publications
No (54)
Yes (1)
Showing 1-25 of 55 results

IHC-plus™ TPH1 / Tryptophan Hydroxylase Antibody (aa26-75) LS-B7001
Rabbit Polyclonal (IgG) to Human TPH1 / Tryptophan Hydroxylase
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-TPH1 / TPH antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Immunofluorescence analysis of HepG2 cells, using Tryptophan Hydroxylase Antibody. The picture on the right is blocked with the synthesized peptide.

TPH1 / Tryptophan Hydroxylase Antibody (aa231-280) LS-C117936
Publications (1)
Publications (1)
Rabbit Polyclonal (IgG) to Human TPH1 / Tryptophan Hydroxylase
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Tryptophan Hydroxylase Antibody. The picture on the right is blocked with the synthesized peptide.
Immunofluorescence analysis of HUVEC cells, using Tryptophan Hydroxylase Antibody. The picture on the right is blocked with the synthesized peptide.

IHC-plus™ TPH1 / Tryptophan Hydroxylase Antibody LS-B7709
Sheep Polyclonal to Rabbit TPH1 / Tryptophan Hydroxylase
Rabbit, Rat, Mammal, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
50µl  $425.00
Anti-TPH1 / TPH antibody IHC of adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Western blot of human dorsal Raphe nucleus showing specific immunolabeling of the ~55k tryptophan hydroxylase protein.

TPH1 / Tryptophan Hydroxylase Antibody (Internal) LS-C413096
Rabbit Polyclonal to Human TPH1 / Tryptophan Hydroxylase
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $275.00
Immunohistochemical analysis of TPH1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of TPH1 staining in HUVEC cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

TPH1 / Tryptophan Hydroxylase Antibody (N-Terminus) LS-C413050
Rabbit Polyclonal to Human TPH1 / Tryptophan Hydroxylase
Chicken, Rabbit, Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $275.00
Immunohistochemical analysis of TPH1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of TPH1 staining in HepG2 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

TPH1 / Tryptophan Hydroxylase Antibody (40-120 aa) LS-C386474
Rabbit Polyclonal (IgG) to Human TPH1 / Tryptophan Hydroxylase
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of TPH1 antibody

TPH1 / Tryptophan Hydroxylase Antibody (200-280 aa) LS-C386478
Rabbit Polyclonal (IgG) to Human TPH1 / Tryptophan Hydroxylase
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of TPH1 antibody

TPH1 / Tryptophan Hydroxylase Antibody LS-C499967
Rabbit Polyclonal (IgG) to Human TPH1 / Tryptophan Hydroxylase
Mouse, Human
ELISA, IF, WB
Unconjugated
50µg  $285.00; 100µg 5mg/ml  $385.00
Immunofluorescent analysis of U251 cells using TPH1 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Immunofluorescent analysis of U251 cells using TPH1 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

TPH1 / Tryptophan Hydroxylase Antibody (Ser40) LS-C195227
Rabbit Polyclonal to Human TPH1 / Tryptophan Hydroxylase
Human
ICC, IHC, WB
Unconjugated
100µl  $445.00

TPH1 / Tryptophan Hydroxylase Antibody (40-120 aa) LS-C381340
Rabbit Polyclonal (IgG) to Human TPH1 / Tryptophan Hydroxylase
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of Phospho-TPH1 (S58) antibody

TPH1 / Tryptophan Hydroxylase Antibody LS-C809521
Rabbit Polyclonal (IgG) to Human TPH1 / Tryptophan Hydroxylase
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Immunofluorescence Image

TPH1 / Tryptophan Hydroxylase Antibody (aa35-62) LS-C160136
Rabbit Polyclonal to Human TPH1 / Tryptophan Hydroxylase
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400µl  $325.00
Formalin-fixed and paraffin-embedded human brain tissue with TPH1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Confocal immunofluorescence of TPH1 Antibody with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

TPH1 / Tryptophan Hydroxylase Antibody LS-C43104
Sheep Polyclonal (IgG) to Human TPH1 / Tryptophan Hydroxylase
Human
IHC-Fr, WB
Unconjugated
0.1ml  $560.00

IHC-plus™ TPH1 / Tryptophan Hydroxylase Antibody LS-B14377
Rabbit Polyclonal (IgG) to Human TPH1 / Tryptophan Hydroxylase
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50µl  $425.00
Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
Western blot analysis of extracts of THP-1 cell lines, using TPH1 antibody.

TPH1 / Tryptophan Hydroxylase Antibody (Val256) LS-C177761
Rabbit Polyclonal to Human TPH1 / Tryptophan Hydroxylase
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
100µl  $345.00
IHC of TPH1 (V256) pAb in paraffin-embedded human lung carcinoma tissue.
Western blot of TPH1 (V256) pAb in extracts from Jurkat cells.

TPH1 / Tryptophan Hydroxylase Antibody (Lys54) LS-C176562
Rabbit Polyclonal to Human TPH1 / Tryptophan Hydroxylase
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
100µl  $345.00
IHC of TPH1 (K54) pAb in paraffin-embedded human brain tissue.
Western blot of TPH1 (K54) pAb in extracts from HepG2 cells.

TPH1 / Tryptophan Hydroxylase Antibody LS-C195225
Rabbit Polyclonal to Human TPH1 / Tryptophan Hydroxylase
Human
ICC, IHC, WB
Unconjugated
100µl  $445.00

TPH1 / Tryptophan Hydroxylase Antibody (Ser31) LS-C195226
Rabbit Polyclonal to Human TPH1 / Tryptophan Hydroxylase
Human
ICC, IHC, WB
Unconjugated
100µl  $445.00

TPH1 / Tryptophan Hydroxylase Antibody (phospho-Ser260) LS-C199690
Rabbit Polyclonal (IgG) to Human TPH1 / Tryptophan Hydroxylase
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using Tryptophan Hydroxylase (Phospho-Ser260) Antibody. The picture on the right is blocked with the phospho peptide.
Western blot analysis of lysates from Jurkat cells and HepG2 cells, using Tryptophan Hydroxylase (Phospho-Ser260) Antibody. The lane on the right is blocked with the phospho peptide.

TPH1 / Tryptophan Hydroxylase Antibody (phospho-Ser58) LS-C199691
Rabbit Polyclonal (IgG) to Human TPH1 / Tryptophan Hydroxylase
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human brain, using Tryptophan Hydroxylase (Phospho-Ser58) Antibody. The picture on the right is blocked with the phospho peptide.
Western blot analysis of lysates from 293 cells treated with paclitaxel 1uM 24h, using Tryptophan Hydroxylase (Phospho-Ser58) Antibody. The lane on the right is blocked with the phospho peptide.

TPH1 / Tryptophan Hydroxylase Antibody (200-280 aa) LS-C381339
Rabbit Polyclonal (IgG) to Human TPH1 / Tryptophan Hydroxylase
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00

TPH1 / Tryptophan Hydroxylase Antibody LS-C681874
Rabbit Polyclonal (IgG) to Mouse TPH1 / Tryptophan Hydroxylase
Mouse
ELISA, IF
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunofluorescent analysis of HepG2 cells diluted at 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

TPH1 / Tryptophan Hydroxylase Antibody LS-C769584
Rabbit Polyclonal (IgG) to Human TPH1 / Tryptophan Hydroxylase
Mouse, Rat, Human
ELISA, IHC-P, WB
Unconjugated
20µl 1mg/ml  $205.00; 60µl 1mg/ml  $235.00; 120µl 1mg/ml  $295.00; 200µl 1mg/ml  $395.00

TPH1 / Tryptophan Hydroxylase Antibody LS-C401093
Rabbit Polyclonal (IgG) to Human TPH1 / Tryptophan Hydroxylase
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20µl 0.2mg/ml  $205.00; 60µl 0.2mg/ml  $235.00; 120µl 0.2mg/ml  $295.00; 200µl 0.2mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human gastric cancer using TPH1 Polyclonal Antibody at dilution of 1:20.
Immunohistochemistry of paraffin-embedded Human gastric cancer using TPH1 Polyclonal Antibody at dilution of 1:20.

TPH1 / Tryptophan Hydroxylase Antibody LS-C404354
Rabbit Polyclonal (IgG) to Human TPH1 / Tryptophan Hydroxylase
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20µl 0.3mg/ml  $205.00; 60µl 0.3mg/ml  $235.00; 120µl 0.3mg/ml  $295.00; 200µl 0.3mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human lung cancer using TPH1 Polyclonal Antibody at dilution of 1:25.
Immunohistochemistry of paraffin-embedded Human lung cancer using TPH1 Polyclonal Antibody at dilution of 1:25.
Showing 1-25 of 55 results

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).