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TP73 / p73

tumor protein p73

This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined.

Gene Name: tumor protein p73
Synonyms: TP73, p53-like transcription factor, p73, p53-related protein, Tumor protein p73
Target Sequences: NM_005427 NP_005418.1 O15350

Publications (1)

1
Directed expression of dominant-negative p73 enables proliferation of cardiomyocytes in mice. Ebelt H, Zhang Y, Khler K, Xu J, Gajawada P, Boettger T, Hollemann T, Mller-Werdan U, Werdan K, Braun T. Journal of molecular and cellular cardiology. 2008 45:411-9. (IP) [PubMed:18634800]

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Products
Proteins (7)
Over-Expression Lysate (4)
Recombinant (3)
TP73 / p73 (7)
No (7)
GST (1)
Myc-DDK (Flag) (6)
Human (5)
293T Cells (2)
HEK 293 Cells (4)
Wheat Germ Extract (1)
Purified (1)
TP73 / p73 Protein - Purified recombinant protein TP73 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
69.4 kDa
20 µg/$1,107
TP73 / p73 Protein - Purified recombinant protein TP73 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
47.5 kDa
20 µg/$1,107
TP73 / p73 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
47.5 kDa
20 µg/$150
TP73 / p73 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
69.4 kDa
20 µg/$215
TP73 / p73 Protein - 12.5% SDS-PAGE of human TP73 stained with Coomassie Blue
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Wheat Germ Extract
GST
96.4 kDa
10 µg/$479; 25 µg/$670
TP73 / p73 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
47.5 kDa
100 µg/$494
TP73 / p73 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
69.4 kDa
100 µg/$710
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).