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TP53 / p53

tumor protein p53

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Gene Name: tumor protein p53
Family/Subfamily: P53 , Not assigned-Other
Synonyms: TP53, BCC7, Cellular tumor antigen p53, p53, TRP53, p53 tumor suppressor, Phosphoprotein p53, Antigen NY-CO-13, Tumor protein p53, Tumor suppressor p53, LFS1
Target Sequences: NM_000546 NP_000537.3 P04637

Publications (9)

1
Cancer. p53, guardian of the genome. Lane DP. Nature. 1992 358:15-6. [PubMed:1614522] Related Antibodies: LS-B431.
2
p53 mutations in human cancers. Hollstein M, Sidransky D, Vogelstein B, Harris CC. Science (New York, N.Y.). 1991 253:49-53. [PubMed:1905840] Related Antibodies: LS-B431.
3
Monoclonal antibodies against simian virus 40 T antigens: evidence for distinct sublcasses of large T antigen and for similarities among nonviral T antigens. Gurney EG, Harrison RO, Fenno J. Journal of virology. 1980 34:752-63. [PubMed:6155477] [PMC:PMC288763] Related Antibodies: LS-B431.
4
Immunohistochemistry in diagnostic surgical pathology: contributions of protein life-cycle, use of evidence-based methods and data normalization on interpretation of immunohistochemical stains. Idikio HA. International journal of clinical and experimental pathology. 2009 3:169-76. (IHC) [PubMed:20126585] [PMC:PMC2809997]
5
Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells. Mandriota SJ, Buser R, Lesne L, Stouder C, Favaudon V, Maechler P, Bna F, Clment V, Regg C, Montesano R, Sappino AP. The Journal of biological chemistry. 2010 285:13092-106. [PubMed:20177072] [PMC:PMC2857118] Related Antibodies: LS-C41085.
6
Inactivation of p53 Is Sufficient to Induce Development of Pulmonary Hypertension in Rats. Jacquin S, Rincheval V, Mignotte B, Richard S, Humbert M, Mercier O, Londoño-Vallejo A, Fadel E, Eddahibi S. PloS one. 2015 10:e0131940. (ICC; Mouse) [Full Text Article] [PubMed:26121334] [PMC:PMC4488287] Related Antibodies: LS-C63152.
7
Stabilization of HIF-1a and HIF-2a, up-regulation of MYCC and accumulation of stabilized p53 constitute hallmarks of CNS-PNET animal model. Malchenko S, Sredni ST, Bi Y, Margaryan NV, Boyineni J, Mohanam I, Tomita T, Davuluri RV, Soares MB. PloS one. 2017 12:e0173106. (IHC, WB; Mouse) [Full Text Article] [PubMed:28249000] [PMC:PMC5332108] Related Antibodies: LS-B7722.
8
Effects of autophagy regulation of tumor-associated macrophages on radiosensitivity of colorectal cancer cells. Shao LN, Zhu BS, Xing CG, Yang XD, Young W, Cao JP. Molecular medicine reports. 2016 13:2661-70. (WB; Human) [Full Text Article] [PubMed:26821367] Related Antibodies: LS-C11553.
9
Clarifying the biological significance of the CHK2 K373E somatic mutation discovered in The Cancer Genome Atlas database. Higashiguchi M, Nagatomo I, Kijima T, Morimura O, Miyake K, Minami T, Koyama S, Hirata H, Iwahori K, Takimoto T, Takeda Y, Kida H, Kumanogoh A. FEBS letters. 2016 December;590:4275-4286. (Human) [Full Text Article] [PubMed:27716909] Related Antibodies: LS-C178095.
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Products
Proteins (26)
Over-Expression Lysate (8)
Recombinant (18)
TP53 / p53 (26)
No (26)
6His, N-terminus (2)
DDK,C-terminus (1)
GST (2)
GST, N-terminus (1)
GST-His, N-terminus (1)
His (2)
His, N-Terminal (2)
His-GST (1)
His-SUMO (2)
Myc-DDK (Flag) (11)
Myc-DDK (Flag), C-terminus (1)
Human (18)
Mouse (2)
Rat (2)
293T Cells (4)
E. coli (9)
HEK 293 Cells (8)
Sf9 Cells (1)
Wheat Germ Extract (3)
Yeast (1)
Purified (6)
Low endotoxin level (1)
TP53 / p53 Protein
Select
E. coli
His-SUMO
59.1 kD
1 mg/$1,646; 100 µg/$490; 20 µg/$354
TP53 / p53 Protein - Recombinant Tumor Protein p53 By SDS-PAGE
Select
E. coli
His, N-Terminal
33.4 kDa
10 µg/$284; 50 µg/$498; 100 µg/$793; 200 µg/$993; 1 mg/$2,145; 500 µg/$1,571; 5 mg/$4,730
TP53 / p53 Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
Select
E. coli
6His, N-terminus
46.3 kDa
10 µg/$255; 50 µg/$305; 100 µg/$355
Select
E. coli
His
47.5 kD
1 mg/$1,646; 100 µg/$490; 20 µg/$354
TP53 / p53 Protein
Select
E. coli
His-SUMO
59.49 kD
1 mg/$1,207; 100 µg/$408; 20 µg/$311
TP53 / p53 Protein - Recombinant Tumor Protein p53 By SDS-PAGE
Select
E. coli
His
Less than 1.0 EU/µg protein (determined by LAL method).
30.3 kDa
10 µg/$281; 50 µg/$479; 100 µg/$765; 200 µg/$955; 1 mg/$2,079; 500 µg/$1,527; 5 mg/$4,565
TP53 / p53 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Yeast
6His, N-terminus
500 µg/$1,000; 100 µg/$436; 20 µg/$326
TP53 / p53 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$469; 25 µg/$630
TP53 / p53 Protein
Select
E. coli
His-GST
41.3 kDa
10 µg/$284; 50 µg/$498; 100 µg/$793; 200 µg/$993; 1 mg/$2,145; 500 µg/$1,571; 5 mg/$4,730
TP53 / p53 Protein - Purified recombinant protein TP53 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
43.5 kDa
20 µg/$1,005
TP53 / p53 Protein - Purified recombinant protein TP53 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
43.5 kDa
20 µg/$1,005
TP53 / p53 Protein - Purified recombinant protein TP53 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
37.6 kDa
20 µg/$1,005
TP53 / p53 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
43.5 kDa
20 µg/$130
Select
293T Cells
Myc-DDK (Flag)
44.1 kDa
20 µg/$130
TP53 / p53 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
38.3 kDa
20 µg/$130
TP53 / p53 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
37.6 kDa
20 µg/$130
TP53 / p53 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
44.1 kDa
100 µg/$458
TP53 / p53 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
38.3 kDa
100 µg/$458
TP53 / p53 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
37.6 kDa
100 µg/$458
TP53 / p53 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
43.5 kDa
100 µg/$458
TP53 / p53 Protein - 12.5% SDS-PAGE of human TP53 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
68.86 kDa
2 µg/$429
TP53 / p53 Protein - 12.5% SDS-PAGE of human TP53 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
68.97 kDa
10 µg/$469; 25 µg/$630
TP53 / p53 Protein
Select
HEK 293 Cells
Myc-DDK (Flag), C-terminus
43.6 kDa
20 µg/$1,005
TP53 / p53 Protein
Select
Sf9 Cells
DDK,C-terminus
44 kDa
20 µg/$577
TP53 / p53 Protein
Select
E. coli
GST-His, N-terminus
72.5 kDa
50 µg/$390
Viewing 1-25 of 26 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).