TP53 / p53

tumor protein p53

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

☰ Filters

Products

Proteins (26)

Type

Over-Expression Lysate (8)

Recombinant (18)

Target

TP53 / p53 (26)

Publications

No (26)

Tag

6His, N-terminus (2)

DDK,C-terminus (1)

GST (2)

GST, N-terminus (1)

GST-His, N-terminus (1)

His (2)

His, N-Terminal (2)

His-GST (1)

His-SUMO (2)

Myc-DDK (Flag) (11)

Myc-DDK (Flag), C-terminus (1)

more less

Species

Human (18)

Mouse (2)

Rat (2)

Source

293T Cells (4)

E. coli (9)

HEK 293 Cells (8)

Sf9 Cells (1)

Wheat Germ Extract (3)

Yeast (1)

Purification

Purified (6)

Select

Human TP53 / p53 Protein (Recombinant His, N-Terminal) (Gly108-Lys370) - LS-G13175

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

33.4 kDa

Price:

10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383

Select

Mouse TP53 / p53 Protein (Recombinant His-SUMO) (Full Length) - LS-G21279

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

59.1 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

Select

Human TP53 / p53 Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G26547

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

46.3 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365

Select

Mouse TP53 / p53 Protein (Recombinant His) (aa137-390) - LS-G13168

Source:

E. coli

Tag:

His

Molecular Weight:

30.3 kDa

Price:

10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334

Select

Human TP53 / p53 Protein (Recombinant 6His, N-terminus) (aa1-393) - LS-G57274

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

Select

Rat TP53 / p53 Protein (Recombinant His) (Full Length) - LS-G22669

Source:

E. coli

Tag:

His

Molecular Weight:

47.5 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

Select

Human TP53 / p53 Protein (Recombinant His-SUMO) (Full Length) - LS-G21278

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

59.49 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

Select

Human TP53 / p53 Protein (Recombinant GST, N-terminus) (aa94-201) - LS-G60400

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human TP53 / p53 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69732

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.5 kDa

Price:

20 µg/$1,107

Select

Human TP53 / p53 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69733

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.5 kDa

Price:

20 µg/$1,107

Select

Human TP53 / p53 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69734

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.6 kDa

Price:

20 µg/$1,107

Select

Human TP53 / p53 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85433

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.5 kDa

Price:

20 µg/$150

Select

Human TP53 / p53 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85434

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.1 kDa

Price:

20 µg/$150

Select

Human TP53 / p53 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85435

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38.3 kDa

Price:

20 µg/$150

Select

Human TP53 / p53 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85436

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.6 kDa

Price:

20 µg/$150

Select

Rat TP53 / p53 Protein (Recombinant His, N-Terminal) (Pro90-Ala354) - LS-G13174

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

33.8 kDa

Price:

50 µg/$482; 10 µg/$287; 200 µg/$962; 100 µg/$770; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

Select

Human TP53 / p53 Protein (Recombinant His-GST) (Met1-Asp393) - LS-G24161

Source:

E. coli

Tag:

His-GST

Molecular Weight:

41.3 kDa

Price:

10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383

Select

Human TP53 / p53 Protein (Recombinant GST) (Full Length) - LS-G30748

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

68.86 kDa

Price:

2 µg/$439

Select

Human TP53 / p53 Protein (Recombinant GST) (Full Length) - LS-G30747

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

68.97 kDa

Price:

10 µg/$479; 25 µg/$670

Select

Human TP53 / p53 Protein (Recombinant GST-His, N-terminus) - LS-G143845

Source:

E. coli

Tag:

GST-His, N-terminus

Molecular Weight:

72.5 kDa

Price:

50 µg/$419

Select

Human TP53 / p53 Protein (Recombinant Myc-DDK (Flag), C-terminus) - LS-G142297

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag), C-terminus

Molecular Weight:

43.6 kDa

Price:

20 µg/$1,107

Select

Human TP53 / p53 Protein (Recombinant DDK,C-terminus) - LS-G142327

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

44 kDa

Price:

20 µg/$677

Select

TP53 / p53 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124513

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.5 kDa

Price:

100 µg/$494

Select

TP53 / p53 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124515

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38.3 kDa

Price:

100 µg/$494

Select

TP53 / p53 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124516

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.6 kDa

Price:

100 µg/$494

Viewing 1-25 of 26 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.