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Unfortunately, the antibody (ID:89000) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



TP53 / p53

tumor protein p53

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Gene Name: tumor protein p53
Family/Subfamily: P53 , Not assigned-Other
Synonyms: TP53, BCC7, Cellular tumor antigen p53, p53, TRP53, p53 tumor suppressor, Phosphoprotein p53, Antigen NY-CO-13, Tumor protein p53, Tumor suppressor p53, LFS1
Target Sequences: NM_000546 NP_000537.3 P04637

Publications (8)

1
Cancer. p53, guardian of the genome. Lane DP. Nature. 1992 358:15-6. [PubMed:1614522] Related Antibodies: LS-B431.
2
p53 mutations in human cancers. Hollstein M, Sidransky D, Vogelstein B, Harris CC. Science (New York, N.Y.). 1991 253:49-53. [PubMed:1905840] Related Antibodies: LS-B431.
3
Monoclonal antibodies against simian virus 40 T antigens: evidence for distinct sublcasses of large T antigen and for similarities among nonviral T antigens. Gurney EG, Harrison RO, Fenno J. Journal of virology. 1980 34:752-63. [PubMed:6155477] [PMC:PMC288763] Related Antibodies: LS-B431.
4
Immunohistochemistry in diagnostic surgical pathology: contributions of protein life-cycle, use of evidence-based methods and data normalization on interpretation of immunohistochemical stains. Idikio HA. International journal of clinical and experimental pathology. 2009 3:169-76. (IHC) [PubMed:20126585] [PMC:PMC2809997]
5
Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells. Mandriota SJ, Buser R, Lesne L, Stouder C, Favaudon V, Maechler P, Bna F, Clment V, Regg C, Montesano R, Sappino AP. The Journal of biological chemistry. 2010 285:13092-106. [PubMed:20177072] [PMC:PMC2857118] Related Antibodies: LS-C41085.
6
Inactivation of p53 Is Sufficient to Induce Development of Pulmonary Hypertension in Rats. Jacquin S, Rincheval V, Mignotte B, Richard S, Humbert M, Mercier O, Londoño-Vallejo A, Fadel E, Eddahibi S. PloS one. 2015 10:e0131940. (ICC; Mouse) [Full Text Article] [PubMed:26121334] [PMC:PMC4488287] Related Antibodies: LS-C63152.
7
Stabilization of HIF-1a and HIF-2a, up-regulation of MYCC and accumulation of stabilized p53 constitute hallmarks of CNS-PNET animal model. Malchenko S, Sredni ST, Bi Y, Margaryan NV, Boyineni J, Mohanam I, Tomita T, Davuluri RV, Soares MB. PloS one. 2017 12:e0173106. (IHC, WB; Mouse) [Full Text Article] [PubMed:28249000] [PMC:PMC5332108] Related Antibodies: LS-B7722.
8
Effects of autophagy regulation of tumor-associated macrophages on radiosensitivity of colorectal cancer cells. Shao LN, Zhu BS, Xing CG, Yang XD, Young W, Cao JP. Molecular medicine reports. 2016 13:2661-70. (WB; Human) [Full Text Article] [PubMed:26821367] Related Antibodies: LS-C11553.
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aa16-65 (1)
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aa20-26 (1)
aa213-217 (1)
Publications
No (684)
Yes (5)
Showing 1-25 out of 689 results
Anti-TP53 / p53 Antibody (clone BP53-12) IHC-plus™ LS-B431
Anti-TP53 / p53 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B431 concentration 5 ug/ml.
Immunofluorescence microscopy of HeLa cells using anti-p53 a 1:100 dilution.  Personnel Communication.  Kuldeep Patel, Loyola University.

Mouse Monoclonal [clone BP53-12] (IgG2a,k) to Human TP53 / p53
Human
ELISA ICC IF IHC IHC-P IP WB
Unconjugated
Anti-TP53 / p53 Antibody (aa283-332) IHC-plus™ LS-B7722
Anti-p53 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7722 dilution 10 ug/ml.
Immunofluorescence of HeLa cells, using p53 (Ab-317) Antibody. The picture on the right is treated with the synthesized peptide.

Rabbit Polyclonal (IgG) to Human TP53 / p53
Mouse, Rat, Human
ELISA IF IHC IHC-P WB
Unconjugated
Anti-TP53 / p53 Antibody (aa20-25, clone DO-1) LS-C11553

Mouse Monoclonal [clone DO-1] (IgG2a) to Human TP53 / p53
Bovine, Cat, Horse, Human
ELISA IHC IHC-Fr IHC-P IP WB
Unconjugated
Anti-TP53 / p53 Antibody (clone 6F2D3) LS-C203312

Mouse Monoclonal [clone 6F2D3] (IgG1) to Human TP53 / p53
Human
ELISA Flo WB
Unconjugated
Anti-TP53 / p53 Antibody LS-C50534
Colon carcinoma stained with anti-p53 antibody

Rabbit Polyclonal to Human TP53 / p53
Human
IHC
Unconjugated
Anti-TP53 / p53 Antibody (clone PAb 122) LS-C63152

Mouse Monoclonal [clone PAb 122] (IgG1,k) to Mouse TP53 / p53
Mouse, Rat, Human
ICC IHC IP WB
Unconjugated
Anti-TP53 / p53 Antibody (clone BP53-12) LS-C41085
MCF-7 cell extract was resolved by electrophoresis, transferred to nitrocellulose and probed with monoclonal anti-p53 (clone BP53-12) antibody. Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a chemiluminescence detection

Mouse Monoclonal [clone BP53-12] (IgG2a) to Human TP53 / p53
Human, Primate
ELISA ICC IHC IHC-P IP WB
Unconjugated
Anti-TP53 / p53 Antibody (clone PAb240) LS-C134559

Mouse Monoclonal [clone PAb240] (IgG1,k) to Mouse TP53 / p53
Chicken, Bovine, Rat, Hamster, Mouse, Human
Flo IHC WB
Unconjugated
Anti-TP53 / p53 Antibody (clone PAb240, Biotin) LS-C134560
Flow cytometry of TP53 / p53 antibody This image was taken for the unconjugated form of this product. Other forms have not been tested.

Mouse Monoclonal [clone PAb240] (IgG1,k) to Mouse TP53 / p53
Chicken, Bovine, Rat, Hamster, Mouse, Human
Flo IHC WB
Biotin Conjugated
Anti-TP53 / p53 Antibody (N-Terminus) IHC-plus™ LS-B4558
Anti-TP53 / p53 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4558 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
TP53 / p53 antibody LS-B4558 Western blot of 293T cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rabbit Polyclonal to Human TP53 / p53
Human
IHC IHC-P WB
Unconjugated
Anti-TP53 / p53 Antibody (N-Terminus) IHC-plus™ LS-B4557
Anti-TP53 / p53 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4557 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-TP53 / p53 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4557 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rabbit Polyclonal to Human TP53 / p53
Sheep, Bovine, Pig, Human
IHC IHC-P WB
Unconjugated
Anti-TP53 / p53 Antibody (aa181-190, clone DO-11) LS-C11558

Mouse Monoclonal [clone DO-11] (IgG1) to Human TP53 / p53
Human
IHC IHC-Fr IHC-P IP WB
Unconjugated
Anti-TP53 / p53 Antibody (phospho-Ser20) IHC-plus™ LS-B14320
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Immunofluorescent analysis of p53 (pS20) staining in HCT116 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

Rabbit Polyclonal to Human TP53 / p53
Rabbit, Pig, Human, Monkey
ICC IF IHC IHC-P WB
Unconjugated
Anti-TP53 / p53 Antibody (clone 5E2) LS-C172956
IHC of paraffin-embedded Carcinoma of Human lung tissue using anti-TP53 mouse monoclonal antibody.
IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-TP53 mouse monoclonal antibody.

Mouse Monoclonal [clone 5E2] (IgG1) to Human TP53 / p53
Mouse, Human, Monkey
Flo IF IHC IHC-P WB
Unconjugated
Anti-TP53 / p53 Antibody (aa281-330) LS-C30932
SP2/0 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rabbit Polyclonal (IgG) to Mouse TP53 / p53
Mouse, Dog, Sheep, Bovine, Rat, Pig, Horse, Human, Monkey
WB
Unconjugated
Anti-TP53 / p53 Antibody (aa10-59) IHC-plus™ LS-B7579
Anti-TP53 / p53 antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7579 dilution 1:100.
Immunofluorescence of HeLa cells, using p53 Antibody. The picture on the right is treated with the synthesized peptide.

Rabbit Polyclonal (IgG) to Human TP53 / p53
Mouse, Rat, Human
ELISA IF IHC IHC-P WB
Unconjugated
Anti-TP53 / p53 Antibody (aa344-393) IHC-plus™ LS-B7723
Anti-p53 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7723 dilution 10 ug/ml.
Immunofluorescence of HeLa cells, using p53 (Ab-382) Antibody. The picture on the right is treated with the synthesized peptide.

Rabbit Polyclonal (IgG) to Human TP53 / p53
Mouse, Rat, Human
ELISA IF IHC IHC-P WB
Unconjugated
Anti-TP53 / p53 Antibody (Acetyl-Lys379) IHC-plus™ LS-B6757
Anti-TP53 / p53 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6757 dilution 1:200.
Immunofluorescence of HeLa cells, using p53 (Acetyl-Lys379) Antibody. The picture on the right is treated with the synthesized peptide.

Rabbit Polyclonal (IgG) to Human TP53 / p53
Mouse, Rat, Human
ELISA IF IHC IHC-P
Unconjugated
Anti-TP53 / p53 Antibody (N-Terminus) LS-C413125
Immunohistochemical analysis of p53 staining in human colon cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of p53 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

Rabbit Polyclonal to Human TP53 / p53
Pig, Human, Monkey
ICC IF IHC IHC-P WB
Unconjugated
Anti-TP53 / p53 Antibody (C-Terminus) LS-C30938

Rabbit Polyclonal (IgG) to Human TP53 / p53
Human
WB
Unconjugated
Anti-TP53 / p53 Antibody (Di-Methyl-Lys370) LS-C380585
Western blot of Di-Methyl-p53 (K370) antibody

Rabbit Polyclonal (IgG) to Human TP53 / p53
Human
ELISA IF IHC IHC-P WB
Unconjugated
Anti-TP53 / p53 Antibody (Ser315) IHC-plus™ LS-B9038
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Fluorescent confocal image of U251 cell stained with p53 Antibody (S315). U251 cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with p53 primary antibody (1:25, 1 h at 37°C). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37°C). Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37°C). Nuclei were counterstained with DAPI (blue) (10 ug/ml, 10 min). p53 immunoreactivity is localized to Nucleus significantly.

Rabbit Polyclonal to Human TP53 / p53
Human
IF IHC IHC-P WB
Unconjugated
Anti-TP53 / p53 Antibody (clone DO-1) LS-C179709
Immunohistochemistry Image

Mouse Monoclonal [clone DO-1] (IgG2a)
Human
IHC IHC-P IP WB
Unconjugated
Anti-TP53 / p53 Antibody (aa16-30) LS-C26646
Western blot of Anti-p53 clone. X77 antibody at 10 ug/ml on HCT116 cell lysate (1), HCT116 cell lysate activated with Adriamycin (2), p21-/- cell lysate (3), P21-/- cell lysate activated with ADR (4) and p53-/- activated with ADR. ADR activates p53 in cells. Also shown is a graphic representation of the epitope location.

Mouse Monoclonal (IgG1)
Xenopus, Mouse, Human
ELISA IF WB
Unconjugated
Anti-TP53 / p53 Antibody LS-C497674
Immunohistochemistry of paraffin-embedded mouse prostate.
Immunohistochemistry of paraffin-embedded human gastric cancer tissue.

Rabbit Monoclonal (IgG) to Human TP53 / p53
Mouse, Rat, Human
IHC IP WB
Unconjugated

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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