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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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TOPORS
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.
| Gene Name: | topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase |
| Synonyms: | TOPORS, p53-binding protein 3, LUN, SUMO1-protein E3 ligase Topors, TP53BPL, RP31, p53BP3 |
| Target Sequences: | NM_005802 NP_005793.2 Q9NS56 |
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