TOPBP1

topoisomerase (DNA) II binding protein 1

Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

TOPBP1 (6)

Publications

No (6)

Tag

GST, N-terminus (1)

His-T7, N-terminus (2)

Myc-DDK (Flag) (2)

Species

Human (3)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human TOPBP1 Protein (Recombinant His-T7, N-terminus) (Met1-Lys250) - LS-G133416

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

31.6kDa

Price:

10 µg/$271; 50 µg/$377; 200 µg/$752; 100 µg/$602; 1 mg/$1,804; 500 µg/$1,367; 5 mg/$2,762; 2 mg/$1,985

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Mouse TOPBP1 Protein (Recombinant) (Met1-Pro246) - LS-G133720

Source:

E. coli

Tag:

None

Molecular Weight:

32.0kDa

Price:

10 µg/$274; 50 µg/$397; 200 µg/$792; 100 µg/$635; 1 mg/$1,864; 500 µg/$1,419; 5 mg/$2,826; 2 mg/$2,047

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TOPBP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114909

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

171.1 kDa

Price:

100 µg/$710

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Human TOPBP1 Protein (Recombinant GST, N-terminus) (aa1327-1435) - LS-G61733

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TOPBP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81045

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

171.1 kDa

Price:

20 µg/$215

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Rat TOPBP1 Protein (Recombinant His-T7, N-terminus) (Met1-Pro246) - LS-G133601

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

32.0kDa

Price:

10 µg/$277; 50 µg/$417; 200 µg/$832; 100 µg/$667; 1 mg/$1,922; 500 µg/$1,470; 5 mg/$2,913; 2 mg/$2,107

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