TOP3A

topoisomerase (DNA) III alpha

Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity.

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Products

Antibodies (12)

ELISA Kits (1)

Proteins (1)

Type

Primary (12)

Recombinant (1)

Sandwich (1)

Target

TOP3A (14)

Reactivity

Human (13)

Mouse (2)

Bovine (1)

Dog (1)

Zebrafish (1)

Application

WB (12)

ELISA (2)

IF (1)

IP (1)

Peptide-ELISA (1)

Host

rabbit (12)

Isotype

IgG (3)

Clonality

polyclonal pc (12)

Format

96-Well Strip Plate (1)

APC (1)

APC Conjugated (1)

Biotin Conjugated (1)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

PE Conjugated (1)

Unconjugated (5)

Epitope

aa35-179 (8)

Internal (1)

Publications

No (14)

Sample Type

Cell Lysates (1)

Tissue Homogenates (1)

Tag

His (1)

Species

Human (1)

Source

E. coli (1)

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TOP3A Antibody (Internal) LS-C354485

Antibody:

TOP3A Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Zebrafish, Dog, Bovine, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$299

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TOP3A Antibody LS-C804542

Antibody:

TOP3A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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TOP3A Antibody LS-C661172

Antibody:

TOP3A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

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TOP3A Antibody LS-C814188

Antibody:

TOP3A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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TOP3A Antibody (aa35-179) LS-C373188

Antibody:

TOP3A Rabbit anti-Human Polyclonal (aa35-179) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

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TOP3A Antibody (aa35-179, HRP) LS-C712760

Antibody:

TOP3A Rabbit anti-Human Polyclonal (aa35-179) (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$338; 200 µl/$393; 500 µl/$575; 1 ml/$702; 2 ml/$939; 5 ml/$1,593

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TOP3A Antibody (aa35-179, Biotin) LS-C688101

Antibody:

TOP3A Rabbit anti-Human Polyclonal (aa35-179) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348

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TOP3A Antibody (aa35-179, FITC) LS-C695020

Antibody:

TOP3A Rabbit anti-Human Polyclonal (aa35-179) (FITC) Antibody

Reactivity:

Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716

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TOP3A Antibody (aa35-179, PE) LS-C726822

Antibody:

TOP3A Rabbit anti-Human Polyclonal (aa35-179) (PE) Antibody

Reactivity:

Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

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TOP3A Antibody (aa35-179, APC) LS-C741182

Antibody:

TOP3A Rabbit anti-Human Polyclonal (aa35-179) (APC) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

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TOP3A Antibody (aa35-179, APC, Cy7) LS-C735744

Antibody:

TOP3A Rabbit anti-Human Polyclonal (aa35-179) (APC, Cy7) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$505; 200 µl/$648; 500 µl/$1,152; 1 ml/$1,401; 2 ml/$1,961; 5 ml/$3,676

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TOP3A Antibody (aa35-179, Cy3) LS-C703740

Antibody:

TOP3A Rabbit anti-Human Polyclonal (aa35-179) (Cy3) Antibody

Reactivity:

Human

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

• Unconjugated
• HRP
• Biotin
• FITC
• PE
• APC
• APC, Cy7
• More...
  • Cy3

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • PE
  • APC
  • APC, Cy7
  • Cy3

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Human TOP3A Protein (Recombinant His) (aa35-179) - LS-G25370

Source:

E. coli

Tag:

His

Molecular Weight:

20.6 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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Human TOP3A (Sandwich ELISA) ELISA Kit - LS-F8268

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

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