TOP2B / Topoisomerase II Beta

topoisomerase (DNA) II beta 180kDa

TOP2B / Topoisomerase II Beta is a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described.

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ELISA Kits (6)

Type

Cell-Based (1)

Custom (3)

Sandwich (2)

Target

TOP2B / Topoisomerase II Beta (6)

Reactivity

Human (4)

Mouse (2)

Chicken (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (5)

Publications

No (6)

Sample Type

Adherent Cell Cultures (1)

Plasma (1)

Serum (1)

Tissue Homogenates (2)

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Human TOP2B / Topoisomerase II Beta (Custom ELISA) ELISA Kit - LS-F16347

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Mouse TOP2B / Topoisomerase II Beta (Custom ELISA) ELISA Kit - LS-F16348

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Chicken TOP2B / Topoisomerase II Beta (Custom ELISA) ELISA Kit - LS-F16349

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$929

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Human TOP2B / Topoisomerase II Beta (Sandwich ELISA) ELISA Kit - LS-F32910

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse/Human TOP2B / Topoisomerase II Beta (Cell-Based ELISA) ELISA Kit - LS-F2361

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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Human TOP2B / Topoisomerase II Beta (Sandwich ELISA) ELISA Kit - LS-F6881

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$834

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