TOP2B / Topoisomerase II Beta

topoisomerase (DNA) II beta 180kDa

TOP2B / Topoisomerase II Beta is a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described.

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Products

Antibodies (34)

Type

Primary (34)

Target

TOP2B / Topoisomerase II Beta (34)

Reactivity

Human (34)

Mouse (19)

Rat (6)

Bat (3)

Chimpanzee (6)

Dog (7)

Gibbon (6)

Guinea pig (6)

Horse (6)

Monkey (7)

Orangutan (6)

Pig (7)

Rabbit (6)

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Application

IHC (12)

IHC-P (3)

WB (27)

ELISA (6)

ICC (2)

IF (4)

IP (3)

Peptide-ELISA (2)

Host

rabbit (34)

Isotype

IgG (15)

Clonality

polyclonal pc (34)

Format

APC (1)

APC Conjugated (1)

Biotin Conjugated (4)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (1)

Unconjugated (18)

Epitope

aa446-655 (8)

aa1439-1488 (4)

aa1548-1597 (4)

aa1570-C-term (2)

10-90 aa, N-terminal (1)

Ala32 (1)

C-Terminus (1)

N-Terminus (1)

aa1-50 (1)

aa1475-1525 (1)

Publications

No (34)

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TOP2B / Topoisomerase II Beta Antibody (N-Terminus) LS-C352951

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Dog, Pig, Human, Monkey

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

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TOP2B / Topoisomerase II Beta Antibody LS-C661171

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

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TOP2B / Topoisomerase II Beta Antibody LS-C800402

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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TOP2B / Topoisomerase II Beta Antibody (10-90 aa, N-terminal) LS-C386465

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Human Polyclonal (10-90 aa, N-terminal) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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TOP2B / Topoisomerase II Beta Antibody LS-C827604

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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TOP2B / Topoisomerase II Beta Antibody LS-C820568

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF

Format:

Unconjugated

Price:

100 µl/$412

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TOP2B / Topoisomerase II Beta Antibody (aa1570-C-term) LS-C287782

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Human Polyclonal (aa1570-C-term) Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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TOP2B / Topoisomerase II Beta Antibody (aa1475-1525) LS-C287783

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Human Polyclonal (aa1475-1525) Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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TOP2B / Topoisomerase II Beta Antibody LS-C670070

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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TOP2B / Topoisomerase II Beta Antibody (aa1-50) LS-C118622

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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TOP2B / Topoisomerase II Beta Antibody (Ala32) LS-C176355

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Human Polyclonal (Ala32) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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TOP2B / Topoisomerase II Beta Antibody (C-Terminus) LS-C137150

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

100 µl/$332

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TOP2B / Topoisomerase II Beta Antibody LS-C136868

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$332

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TOP2B / Topoisomerase II Beta Antibody (aa1570-C-term) LS-C285926

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Human Polyclonal (aa1570-C-term) Antibody

Reactivity:

Human

Applications:

IHC

Format:

Unconjugated

Price:

0.5 µg/$295; 100 µl/$532

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TOP2B / Topoisomerase II Beta Antibody (aa446-655) LS-C296718

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Mouse Polyclonal (aa446-655) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261

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TOP2B / Topoisomerase II Beta Antibody (aa446-655, HRP) LS-C712757

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Mouse Polyclonal (aa446-655) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722; 2 ml/$959; 5 ml/$1,639

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TOP2B / Topoisomerase II Beta Antibody (aa446-655, Biotin) LS-C688103

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Mouse Polyclonal (aa446-655) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387

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TOP2B / Topoisomerase II Beta Antibody (aa446-655, FITC) LS-C695018

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Mouse Polyclonal (aa446-655) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765

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TOP2B / Topoisomerase II Beta Antibody (aa446-655, Cy3) LS-C703735

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Mouse Polyclonal (aa446-655) (Cy3) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

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TOP2B / Topoisomerase II Beta Antibody (aa446-655, APC) LS-C718445

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Mouse Polyclonal (aa446-655) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

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TOP2B / Topoisomerase II Beta Antibody (aa446-655, APC, Cy7) LS-C735742

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Mouse Polyclonal (aa446-655) (APC, Cy7) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$513; 200 µl/$666; 500 µl/$1,175; 1 ml/$1,441; 2 ml/$2,017; 5 ml/$3,781

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TOP2B / Topoisomerase II Beta Antibody (aa446-655, PE) LS-C726820

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Mouse Polyclonal (aa446-655) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

• Unconjugated
• HRP
• Biotin
• FITC
• Cy3
• APC
• APC, Cy7
• More...
  • PE

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • Cy3
  • APC
  • APC, Cy7
  • PE

Select

TOP2B / Topoisomerase II Beta Antibody (aa1548-1597) LS-C110235

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Human Polyclonal (aa1548-1597) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

TOP2B / Topoisomerase II Beta Antibody (aa1439-1488) LS-C109740

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Human Polyclonal (aa1439-1488) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

TOP2B / Topoisomerase II Beta Antibody LS-C357013

Antibody:

TOP2B / Topoisomerase II Beta Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$386

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