TOP1MT

topoisomerase (DNA) I, mitochondrial

Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

☰ Filters

Products

Antibodies (37)

Proteins (4)

Type

Over-Expression Lysate (2)

Primary (37)

Recombinant (2)

Target

TOP1MT (41)

Reactivity

Human (21)

Mouse (13)

Rat (13)

Chimpanzee (3)

Gibbon (3)

Monkey (3)

Orangutan (3)

Application

IHC (7)

IHC-P (9)

WB (25)

Flo (3)

ELISA (6)

IF (6)

Peptide-ELISA (1)

Host

rabbit (31)

mouse (6)

Isotype

IgG (10)

IgG2b,k (6)

Clonality

monoclonal mc (6)

polyclonal pc (29)

recombinant monoclonal rmc (2)

Clone

TOP1MT/2883R (2)

TOP1MT/488 (3)

TPIMT-1 (3)

Format

APC (2)

APC Conjugated (2)

Azide-free (3)

Biotin Conjugated (4)

BSA-free (2)

Carrier-free (1)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (2)

Ready-to-Use (2)

Unconjugated (17)

more less

Epitope

aa522-571 (4)

Publications

No (41)

Tag

His-T7, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (1)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Purification

Purified (2)

Select

TOP1MT Antibody LS-C754508

Antibody:

TOP1MT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$351

Select

TOP1MT Antibody (clone TOP1MT/488) LS-C390003

Antibody:

TOP1MT Mouse anti-Human Monoclonal (TOP1MT/488) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P

Format:

Unconjugated

Price:

20 µg/$371; 100 µg/$574

Select

TOP1MT Antibody (clone TOP1MT/488, Azide-free, BSA-free) LS-C390005

Antibody:

TOP1MT Mouse anti-Human Monoclonal (Azide-free, BSA-free) (TOP1MT/488) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P

Format:

Unconjugated, Azide-free, BSA-free

Price:

100 µg/$574

Select

TOP1MT Antibody (clone TOP1MT/488, Ready-to-Use) LS-C390004

Antibody:

TOP1MT Mouse anti-Human Monoclonal (Ready-to-Use) (TOP1MT/488) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P

Format:

Unconjugated, Ready-to-Use

Price:

7 ml/$574

• Unconjugated
• Unconjugated, Azide-free, BSA-free
• Unconjugated, Ready-to-Use

• Unconjugated
• Unconjugated, Azide-free, BSA-free
• Unconjugated, Ready-to-Use

Select

TOP1MT Antibody (clone TPIMT-1) LS-C391792

Antibody:

TOP1MT Mouse anti-Human Monoclonal (TPIMT-1) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P

Format:

Unconjugated

Price:

20 µg/$371; 100 µg/$574

Select

TOP1MT Antibody (clone TPIMT-1, Ready-to-Use) LS-C391794

Antibody:

TOP1MT Mouse anti-Human Monoclonal (Ready-to-Use) (TPIMT-1) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P

Format:

Unconjugated, Ready-to-Use

Price:

7 ml/$574

Select

TOP1MT Antibody (clone TPIMT-1, Azide-free, BSA-free) LS-C391797

Antibody:

TOP1MT Mouse anti-Human Monoclonal (Azide-free, BSA-free) (TPIMT-1) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P

Format:

Unconjugated, Azide-free, BSA-free

Price:

100 µg/$574

• Unconjugated
• Unconjugated, Ready-to-Use
• Unconjugated, Azide-free, BSA-free

• Unconjugated
• Unconjugated, Ready-to-Use
• Unconjugated, Azide-free, BSA-free

Select

TOP1MT Antibody LS-C681587

Antibody:

TOP1MT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

TOP1MT Antibody (HRP) LS-C681592

Antibody:

TOP1MT Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

TOP1MT Antibody (Biotin) LS-C681589

Antibody:

TOP1MT Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

TOP1MT Antibody (FITC) LS-C681590

Antibody:

TOP1MT Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

TOP1MT Antibody LS-C780905

Antibody:

TOP1MT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

TOP1MT Antibody LS-C809950

Antibody:

TOP1MT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

TOP1MT Antibody LS-C664012

Antibody:

TOP1MT Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261

Select

TOP1MT Antibody (HRP) LS-C712752

Antibody:

TOP1MT Rabbit anti-Mouse Polyclonal (HRP) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722; 2 ml/$959; 5 ml/$1,639

Select

TOP1MT Antibody (Biotin) LS-C688099

Antibody:

TOP1MT Rabbit anti-Mouse Polyclonal (Biotin) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387

Select

TOP1MT Antibody (FITC) LS-C695015

Antibody:

TOP1MT Rabbit anti-Mouse Polyclonal (FITC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765

Select

TOP1MT Antibody (Cy3) LS-C703732

Antibody:

TOP1MT Rabbit anti-Mouse Polyclonal (Cy3) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

Select

TOP1MT Antibody (APC) LS-C741179

Antibody:

TOP1MT Rabbit anti-Mouse Polyclonal (APC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

Select

TOP1MT Antibody (PE) LS-C726816

Antibody:

TOP1MT Rabbit anti-Mouse Polyclonal (PE) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

Select

TOP1MT Antibody (APC, Cy7) LS-C735740

Antibody:

TOP1MT Rabbit anti-Mouse Polyclonal (APC, Cy7) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$513; 200 µl/$666; 500 µl/$1,175; 1 ml/$1,441; 2 ml/$2,017; 5 ml/$3,781

• Unconjugated
• HRP
• Biotin
• FITC
• Cy3
• APC
• PE
• More...
  • APC, Cy7

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • Cy3
  • APC
  • PE
  • APC, Cy7

Select

TOP1MT Antibody LS-C771323

Antibody:

TOP1MT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

TOP1MT Antibody (aa522-571) LS-C152187

Antibody:

TOP1MT Rabbit anti-Human Polyclonal (aa522-571) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

TOP1MT Antibody (aa522-571, FITC) LS-C474111

Antibody:

TOP1MT Rabbit anti-Human Polyclonal (aa522-571) (FITC) Antibody

Reactivity:

Rat, Mouse, Human, Monkey, Chimpanzee, Orangutan, Gibbon

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• FITC

• Unconjugated
• FITC

Select

TOP1MT Antibody LS-C750528

Antibody:

TOP1MT Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Viewing 1-25 of 41 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.