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TOCA1 / FNBP1L
formin binding protein 1-like
Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.
| Gene Name: | formin binding protein 1-like |
| Synonyms: | FNBP1L, C1orf39, Formin-binding protein 1-like, Formin binding protein 1-like, TOCA1, Toca-1 |
| Target Sequences: | NM_017737 NP_060207.2 Q5T0N5 |
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