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Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
Gene Name: | trinucleotide repeat containing 6A |
Synonyms: | TNRC6A, CAG repeat protein 26, CAGH26, EDIE, GW1, GW182, GW182 autoantigen, Protein GW1, TNRC6, EMSY interactor protein, KIAA1460 |
Target Sequences: | NM_020847 NP_055309.2 Q8NDV7 |
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