TNR / Tenascin R

tenascin R

Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

TNR / Tenascin R (5)

Publications

No (5)

Tag

GST, N-terminus (1)

His-GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Rat (1)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human TNR / Tenascin R Protein (Recombinant GST, N-terminus) (aa411-519) - LS-G60397

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TNR / Tenascin R Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83637

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

149.4 kDa

Price:

20 µg/$215

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Rat TNR / Tenascin R Protein (Recombinant His-GST, N-terminus) (aa329-588) - LS-G133265

Source:

E. coli

Tag:

His-GST, N-terminus

Molecular Weight:

58.2kDa

Price:

10 µg/$279; 50 µg/$432; 200 µg/$862; 100 µg/$690; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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TNR / Tenascin R Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117445

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

149.4 kDa

Price:

100 µg/$710

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Human TNR / Tenascin R Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69011

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

149.4 kDa

Price:

20 µg/$1,107

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