TNPO1 / Transportin 1

transportin 1

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Mediates nuclear import of ADAR/ADAR1 (isoform 5) in a RanGTP-dependent manner.

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Products

ELISA Kits (13)

Type

Competitive EIA (1)

Sandwich (10)

Sandwich CLIA (2)

Target

TNPO1 / Transportin 1 (13)

Reactivity

Human (4)

Mouse (4)

Rat (1)

Chicken (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Format

12 x 8-Well Microstrips (2)

96-Well Microplate (2)

96-Well Strip Plate (9)

Publications

No (13)

Sample Type

Plasma (9)

Serum (9)

Tissue Homogenates (2)

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Human TNPO1 / Transportin 1 (Sandwich ELISA) ELISA Kit - LS-F27285

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

5 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

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Mouse TNPO1 / Transportin 1 (Sandwich ELISA) ELISA Kit - LS-F34725

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse TNPO1 / Transportin 1 (Sandwich ELISA) ELISA Kit - LS-F20771

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Mouse TNPO1 / Transportin 1 (CLIA) ELISA Kit - LS-F31003

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Mouse TNPO1 / Transportin 1 (Competitive EIA) ELISA Kit - LS-F28634

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

5 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

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Human TNPO1 / Transportin 1 (CLIA) ELISA Kit - LS-F30326

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

0.625 - 40 ng/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Human TNPO1 / Transportin 1 (Sandwich ELISA) ELISA Kit - LS-F21830

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

3.125 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Rat TNPO1 / Transportin 1 (Sandwich ELISA) ELISA Kit - LS-F38726

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Human TNPO1 / Transportin 1 (Sandwich ELISA) ELISA Kit - LS-F34728

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

3.125 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Chicken TNPO1 / Transportin 1 (Sandwich ELISA) ELISA Kit - LS-F48732

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

3.125 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

Monkey TNPO1 / Transportin 1 (Sandwich ELISA) ELISA Kit - LS-F48734

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

3.125 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

Porcine TNPO1 / Transportin 1 (Sandwich ELISA) ELISA Kit - LS-F48735

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

3.125 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

Rabbit TNPO1 / Transportin 1 (Sandwich ELISA) ELISA Kit - LS-F48737

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

3.125 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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