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TNNI1

troponin I type 1 (skeletal, slow)

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.

Gene Name: troponin I type 1 (skeletal, slow)
Synonyms: TNNI1, Troponin I, skeletal, slow, SSTNI, TNN1
Target Sequences: NM_003281 NP_003272.3 P19237

Publications (2)

1
Large increases in plasma fast skeletal muscle troponin I after whole-body eccentric exercises. Large increases in plasma fast skeletal muscle troponin I after whole-body eccentric exercises. Journal of science and medicine in sport. 2020 August;23:776-781. [Full Text Article] [PubMed:32067915]
2
Elevation of fast but not slow troponin I in the circulation of patients with Becker and Duchenne muscular dystrophy. Benjamin L Barthel, Dan Cox, Marissa Barbieri, Michael Ziemba, Volker Straub, Eric P Hoffman, Alan J Russell. Muscle & nerve. 2021 Jul;;64:43-49. [Full Text Article] [PubMed:33683712] [PMC:PMC8362156]

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ELISA Kits (19)
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TNNI1 (19)
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12 x 8-Well Microstrips (1)
96-Well Microplate (1)
96-Well Strip Plate (14)
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TNNI1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
46.88 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$834
TNNI1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$685
TNNI1 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
12.5 - 800 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
TNNI1 ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
2.34 - 150 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
TNNI1 ELISA Kit
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Sandwich
96-Well Microplate
Human
46.875 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
TNNI1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
46.875 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
TNNI1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
39 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$685
TNNI1 ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
2.344 - 150 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
TNNI1 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
TNNI1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
1.875 - 120 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
TNNI1 ELISA Kit
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Development Kit
Antibody Pair and Standard
Mouse
31.2 - 2000 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,282; 1000 Wells/$1,913
TNNI1 ELISA Kit
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Development Kit
Antibody Pair and Standard
Human
93.76 - 6000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,276; 1000 Wells/$1,903
TNNI1 ELISA Kit
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Development Kit
Antibody Pair and Standard
Rat
5 - 320 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
500 Wells/$1,356; 1000 Wells/$2,037
TNNI1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$870
TNNI1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$870
TNNI1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
TNNI1 ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
46.875 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
TNNI1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
2.5 - 160 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$893
TNNI1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$685
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).