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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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TNK2 / ACK1

tyrosine kinase, non-receptor, 2

Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR.

Gene Name: tyrosine kinase, non-receptor, 2
Family/Subfamily: Protein Kinase , ACK
Synonyms: TNK2, ACK, Activated p21cdc42Hs kinase, Ack kinase, ACK-1, ACK1, Activated CDC42 kinase 1, p21cdc42Hs
Target Sequences: NM_005781 NP_005772.3 Q07912

Viewing 1-25 of 68 items
TNK2 / ACK1 Antibody - Anti-TNK2 / ACK1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 1.25 ug/ml.
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Rabbit Polyclonal (IgG) to Human TNK2 / ACK1
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $425.00
TNK2 / ACK1 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal (IgG) to Human TNK2 / ACK1
Human
IF, IHC, IHC-P, WB
Unconjugated
50µl   1.63mg/ml   $425.00
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Rabbit Polyclonal (IgG) to Human TNK2 / ACK1
Human
ELISA, WB
Unconjugated
100µl   $785.00
TNK2 / ACK1 Antibody - Dot blot of anti-Phospho-ACK1-pY518 Antibody on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
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Rabbit Polyclonal to Human TNK2 / ACK1
Human
DB
Unconjugated
400µl   $325.00
TNK2 / ACK1 Antibody - Immunohistochemical analysis of ACK1 (pY284) staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP-conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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Rabbit Polyclonal to Human TNK2 / ACK1
Mouse, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $265.00
TNK2 / ACK1 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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Rabbit Polyclonal to Human TNK2 / ACK1
Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
TNK2 / ACK1 Antibody - 1:100 staining human breast carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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Rabbit Polyclonal (IgG) to Human TNK2 / ACK1
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
TNK2 / ACK1 Antibody - Western blot analysis of lysates from HepG2 cells treated with EGF, using phospho-ACK (Phospho-Tyr518) antibody.
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Rabbit Polyclonal (IgG) to Human TNK2 / ACK1
Rat, Human
ELISA, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
TNK2 / ACK1 Antibody - Western blot of ACK antibody
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Rabbit Polyclonal (IgG) to Human TNK2 / ACK1
Mouse, Human
ELISA, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
TNK2 / ACK1 Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using ACK1 (Phospho-Tyr284) antibody.
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Rabbit Polyclonal (IgG) to Human TNK2 / ACK1
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100µg   $305.00
TNK2 / ACK1 Antibody - Formalin-fixed and paraffin-embedded human Lung carcinoma reacted with ACK1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Select
Rabbit Polyclonal to Human TNK2 / ACK1
Human
Flo, IHC, IHC-P, WB
Unconjugated
400µl   $325.00
TNK2 / ACK1 Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using ACK1 (Phospho-Tyr284) Antibody. The picture on the right is blocked with the phospho peptide.
Select
Rabbit Polyclonal (IgG) to Human TNK2 / ACK1
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
TNK2 / ACK1 Antibody - Immunohistochemistry of paraffin-embedded human breast carcinoma tissue using ACK1 (Phospho-Tyr284) antibody.
Select
Rabbit Polyclonal to Human TNK2 / ACK1
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
100µl   $325.00
Select
Rabbit Polyclonal (IgG) to Human TNK2 / ACK1
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
TNK2 / ACK1 Antibody - Immunohistochemistry of paraffin-embedded Human breast cancer using TNK2 Polyclonal Antibody at dilution of 1:70.
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Rabbit Polyclonal (IgG) to Human TNK2 / ACK1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20µl   0.6mg/ml   $205.00; 60µl   0.6mg/ml   $235.00; 120µl   0.6mg/ml   $295.00; 200µl   0.6mg/ml   $395.00
Select
Rabbit Polyclonal (IgG) to Human TNK2 / ACK1
Human
ELISA, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human TNK2 / ACK1
Human
ELISA, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human TNK2 / ACK1
Human
ELISA, IHC, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human TNK2 / ACK1
Human
ELISA, IHC, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human TNK2 / ACK1
Human
ELISA, IHC, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human TNK2 / ACK1
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human TNK2 / ACK1
Human
ELISA, IHC, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human TNK2 / ACK1
Human
ELISA, IHC, WB
Unconjugated
100µg   $435.00
TNK2 / ACK1 Antibody - Staining HepG2 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
Select
Rabbit Polyclonal (IgG) to Human TNK2 / ACK1
Human
ELISA, IF, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal to Human TNK2 / ACK1
Mouse, Rat, Human
IF, WB
Unconjugated
100µl   1mg/ml   $385.00

Viewing 1-25 of 68 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).