TNIP2 / ABIN-2

TNFAIP3 interacting protein 2

Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

TNIP2 / ABIN-2 (5)

Publications

No (5)

Tag

His-T7 (2)

Myc-DDK (Flag) (3)

Species

Human (2)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

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Human TNIP2 / ABIN-2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72228

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.5 kDa

Price:

20 µg/$1,107

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Human TNIP2 / ABIN-2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91756

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.5 kDa

Price:

20 µg/$150

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Mouse TNIP2 / ABIN-2 Protein (Recombinant His-T7) (aa170-413) - LS-G15692

Source:

E. coli

Tag:

His-T7

Molecular Weight:

31.9 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Rat TNIP2 / ABIN-2 Protein (Recombinant His-T7) (aa20-200) - LS-G15694

Source:

E. coli

Tag:

His-T7

Molecular Weight:

24.4 kDa

Price:

10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231

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TNIP2 / ABIN-2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110018

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.5 kDa

Price:

100 µg/$494

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