TNIK

TRAF2 and NCK interacting kinase

Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.

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Products

Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

TNIK (4)

Publications

No (4)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human TNIK Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G61906

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TNIK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87298

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

154.8 kDa

Price:

20 µg/$215

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Human TNIK Protein (Recombinant GST) (Full Length) - LS-G32713

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

86.7 kDa

Price:

10 µg/$479; 25 µg/$670

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TNIK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G113500

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

154.8 kDa

Price:

100 µg/$710

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