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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TNFSF9 / CD137L

tumor necrosis factor (ligand) superfamily, member 9

TNFSF9 / CD137L is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.

Gene Name: tumor necrosis factor (ligand) superfamily, member 9
Family/Subfamily: TNF , not assigned-TNF
Synonyms: TNFSF9, 4-1BBL, 4-1BB ligand, 4-1BB-L, CD137L, Homolog of mouse 4-1BB-L, Receptor 4-1BB ligand
Target Sequences: NM_003811 NP_003802.1 P41273

Publications (2)

1
Induction of proliferation and monocytic differentiation of human CD34+ cells by CD137 ligand signaling. Jiang D, Yue PS, Drenkard D, Schwarz H. Stem cells (Dayton, Ohio). 2008 26:2372-81. [PubMed:18566330] Related Antibodies: LS-C41003.
2
Expression of CD137 on Hodgkin and Reed-Sternberg cells inhibits T-cell activation by eliminating CD137 ligand expression. Ho WT, Pang WL, Chong SM, Castella A, Al-Salam S, Tan TE, Moh MC, Koh LK, Gan SU, Cheng CK, Schwarz H. Cancer research. 2013 73:652-61. [PubMed:23204227] Related Antibodies: LS-C41003.

Filtered by: None
Target
TNFSF9 / CD137L (69)
Reactivity
Human (42)
Mouse (27)
Rat (3)
Monkey (4)
Application
IHC (10)
IHC-P (6)
WB (46)
Flo (29)
ELISA (23)
Func (1)
ICC (2)
IF (5)
IP (7)
Peptide-ELISA (1)
Host
rabbit (44)
mouse (14)
goat (1)
rat (10)
Isotype
IgG (13)
IgG1 (8)
IgG1,k (4)
IgG2a,k (7)
IgG2b (5)
Clonality
monoclonal mc (24)
polyclonal pc (45)
Clone
41B436 (1)
41B446 (1)
5F4 (3)
ANC5D6 (5)
AT113-2 (1)
TKS-1 (2)
Format
AP Conjugated (1)
APC (2)
APC Conjugated (4)
Azide-free (1)
Biotin Conjugated (11)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (7)
HRP Conjugated (5)
PE Conjugated (6)
PerCP Conjugated (1)
RPE Conjugated (1)
Unconjugated (29)
Epitope
aa105-309 (8)
aa42-253 (8)
aa160-209 (4)
Extracellular Domain (3)
1-80 aa, Internal (1)
Arg69 (1)
Internal (1)
aa24-186 (1)
aa31-80 (1)
aa52-254 (1)
aa71-254 (1)
Publications
No (68)
Yes (1)
Showing 1-25 of 69 results

IHC-plus™ TNFSF9 / CD137L Antibody LS-B7748
Rabbit Polyclonal (IgG) to Human TNFSF9 / CD137L
Human
IHC, IHC-P, WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-4-1BBL / CD137L antibody IHC of human kidney, glomeruli. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.

TNFSF9 / CD137L Antibody (Extracellular Domain, clone 41B436) LS-C344876
Mouse Monoclonal [clone 41B436] (IgG1,k) to Human TNFSF9 / CD137L
Human
ELISA, Flo, ICC, WB
Unconjugated
50µg  $295.00; 100µg  $345.00
Western blot analysis of human CD137L using anti-CD137L (human), mAb (41B436) at 1:2,000dilution. 1: Recombinant humanCD137L (FLAG-tagged). 2: Recombinant mouse CD137L (FLAG-tagged).
FACS: Human CD137L-transfected HEK 293 cells were stained significantly using anti-CD137L (human), mAb (41B436). No binding was detected on empty vector transfected cells.

IHC-plus™ TNFSF9 / CD137L Antibody LS-B7425
Rabbit Polyclonal (IgG) to Human TNFSF9 / CD137L
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg  $425.00
Anti-TNFSF9 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

IHC-plus™ TNFSF9 / CD137L Antibody (aa160-209) LS-B13165
Rabbit Polyclonal to Human TNFSF9 / CD137L
Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl  $485.00
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
TNFSF9 antibody western blot of HepG2 Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

TNFSF9 / CD137L Antibody (clone 5F4, FITC) LS-C179551
Mouse Monoclonal [clone 5F4] (IgG1,k) to Human TNFSF9 / CD137L
Human
Flo
FITC Conjugated
1000µl 0.05mg/ml  $335.00

TNFSF9 / CD137L Antibody (clone 5F4) LS-C41003
Publications (2)
Publications (2)
Mouse Monoclonal [clone 5F4] (IgG1) to Human TNFSF9 / CD137L
Human
Flo
Unconjugated
100µg 0.5mg/ml  $235.00
HuT 78 (T lymphoma cell line) stained with purified 5F4, then detected with biotinylated antimouse IgG followed by Sav-PE.

TNFSF9 / CD137L Antibody (clone AT113-2) LS-C44563
Rat Monoclonal [clone AT113-2] (IgG1) to Mouse TNFSF9 / CD137L
Mouse
Flo, IP
Unconjugated
0.25mg  $395.00

TNFSF9 / CD137L Antibody (Extracellular Domain) LS-C63324
Rat Monoclonal (IgG2b) to Mouse TNFSF9 / CD137L
Mouse
ELISA, Flo, WB
Unconjugated
500µg  $815.00

TNFSF9 / CD137L Antibody (clone ANC5D6) LS-C134761
Mouse Monoclonal [clone ANC5D6] (IgG2a,k) to Human TNFSF9 / CD137L
Human
ELISA, Flo, WB
Unconjugated
100µg 1mg/ml  $345.00
Flow cytometry of TNFSF9 / CD137L antibody

TNFSF9 / CD137L Antibody (clone ANC5D6, Biotin) LS-C134762
Mouse Monoclonal [clone ANC5D6] (IgG2a,k) to Human TNFSF9 / CD137L
Human
ELISA, Flo, Func, WB
Biotin Conjugated
100µg 1mg/ml  $435.00
Flow cytometry of TNFSF9 / CD137L antibody This image was taken for the unconjugated form of this product. Other forms have not been tested.

TNFSF9 / CD137L Antibody (clone ANC5D6, RPE) LS-C134763
Mouse Monoclonal [clone ANC5D6] (IgG2a,k) to Human TNFSF9 / CD137L
Human
ELISA, Flo, WB
RPE Conjugated
120tst  $465.00
Flow cytometry of TNFSF9 / CD137L antibody This image was taken for the unconjugated form of this product. Other forms have not been tested.

TNFSF9 / CD137L Antibody (clone ANC5D6, Azide-free) LS-C134764
Mouse Monoclonal [clone ANC5D6] (IgG2a,k) to Human TNFSF9 / CD137L
Human
ELISA, Flo, WB
Unconjugated, Azide-free
100µg 1mg/ml  $345.00
Flow cytometry of TNFSF9 / CD137L antibody This image was taken for the unmodified form of this product. Other forms have not been tested.

TNFSF9 / CD137L Antibody (clone ANC5D6, Biotin) LS-C35835
Mouse Monoclonal [clone ANC5D6] (IgG2a,k) to Human TNFSF9 / CD137L
Human
ELISA, Flo, WB
Biotin Conjugated
100µg  $635.00

TNFSF9 / CD137L Antibody LS-C211943
Rabbit Polyclonal (IgG) to Human TNFSF9 / CD137L
Human
ELISA, IHC, WB
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human placenta tissue using TNFSF9 Antibody at dilution of 1:100
Immunofluorescence staining of Hela cells with TNFSF9 Antibody at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

TNFSF9 / CD137L Antibody (aa52-254, HRP) LS-C211944
Rabbit Polyclonal (IgG) to Human TNFSF9 / CD137L
Human
ELISA, IHC, WB
HRP Conjugated
50µg  $285.00; 100µg  $385.00

TNFSF9 / CD137L Antibody (Biotin) LS-C211945
Rabbit Polyclonal (IgG) to Human TNFSF9 / CD137L
Human
ELISA, IHC, WB
Biotin Conjugated
50µg  $285.00; 100µg  $385.00

TNFSF9 / CD137L Antibody (FITC) LS-C211946
Rabbit Polyclonal (IgG) to Human TNFSF9 / CD137L
Human
ELISA, IHC, WB
FITC Conjugated
50µg  $285.00; 100µg  $385.00

TNFSF9 / CD137L Antibody LS-C483114
Rabbit Polyclonal to Mouse TNFSF9 / CD137L
Mouse
ELISA, Flo, ICC, IF
Unconjugated
50µl  $275.00; 100µl  $355.00

TNFSF9 / CD137L Antibody (Internal) LS-C354124
Rabbit Polyclonal to Human TNFSF9 / CD137L
Mouse, Rat, Human
WB
Unconjugated
100µl 1mg/ml  $245.00
Western blot analysis of CD137L expression in HeLa (A); SP2/0 (B); H9C2 (C); rat liver (D) whole cell lysates.

TNFSF9 / CD137L Antibody LS-C496911
Rabbit Polyclonal (IgG) to Human TNFSF9 / CD137L
Mouse, Human
WB
Unconjugated
50µl  $235.00; 100µl  $295.00; 200µl  $385.00
Western blot analysis of extracts of various cell lines, using TNFSF9 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 10s.

TNFSF9 / CD137L Antibody (aa24-186) LS-C124832
Mouse Monoclonal (IgG2b) to Human TNFSF9 / CD137L
Human
ELISA, Flo, WB
Unconjugated
100µg  $680.00; 500µg  $1,410.00

TNFSF9 / CD137L Antibody (Extracellular Domain) LS-C124833
Mouse Monoclonal (IgG2b) to Human TNFSF9 / CD137L
Human
ELISA, Flo, WB
Unconjugated
100µg  $650.00

TNFSF9 / CD137L Antibody LS-C809239
Rabbit Polyclonal (IgG) to Human TNFSF9 / CD137L
Human
ELISA, IF, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunofluorescence Image
Western blot Image

TNFSF9 / CD137L Antibody (1-80 aa, Internal) LS-C382516
Rabbit Polyclonal (IgG) to Human TNFSF9 / CD137L
Human
ELISA, IF, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of CD137L antibody
Western blot of CD137L antibody

TNFSF9 / CD137L Antibody (aa31-80) LS-C118890
Rabbit Polyclonal (IgG) to Human TNFSF9 / CD137L
Human
IF, Peptide-ELISA, WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunofluorescence analysis of HeLa cells, using TNFSF9 Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from HUVEC cells, using TNFSF9 Antibody. The lane on the right is blocked with the synthesized peptide.
Showing 1-25 of 69 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).