TNFSF18 / GITRL

tumor necrosis factor (ligand) superfamily, member 18

The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-kB and various mitogen-activated protein kinases. The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions. Its ligand GITRL is expressed in endothelial and antigen-presenting cells and can activate NF-kB, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR. Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-kB activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2.

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Products

Proteins (19)

Type

Over-Expression Lysate (2)

Recombinant (17)

Target

TNFSF18 / GITRL (19)

Publications

No (19)

Tag

6His, C-terminus (2)

DDK (Flag) (1)

DDK,N-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

His, N-Terminal (1)

His,C-terminus (1)

Human IgG1 Fc, C-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (16)

Mouse (2)

Source

293F Cells (1)

293T Cells (1)

E. coli (6)

HEK 293 Cells (7)

Human Cells (1)

Mammalian Cells (1)

Wheat Germ Extract (2)

Purification

Purified (11)

Low Endotoxin Level

Low endotoxin level (10)

Biologically Active

Biologically active (4)

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Mouse TNFSF18 / GITRL Protein (Recombinant) - LS-G27172

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.2 EU/µg protein (determined by LAL method).

Molecular Weight:

14.5 kDa (SDS-PAGE)

Price:

50 µg/$432; 10 µg/$278; 1 mg/$2,653

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Human TNFSF18 / GITRL Protein (Recombinant His, N-Terminal) (Gln72-Ser199) - LS-G132873

Source:

293F Cells

Tag:

His, N-Terminal

Molecular Weight:

15/18kDa

Price:

10 µg/$307; 50 µg/$602; 200 µg/$1,156; 100 µg/$962; 1 mg/$2,369; 500 µg/$1,876; 5 mg/$4,201; 2 mg/$2,562

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Human TNFSF18 / GITRL Protein (Recombinant His,C-terminus) - LS-G134359

Source:

HEK 293 Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 0.06 EU/µg protein (determined by LAL method).

Molecular Weight:

~17 kDa (SDS-PAGE)

Price:

10 µg/$295; 50 µg/$456

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Human TNFSF18 / GITRL Protein (Recombinant DDK,N-terminus) - LS-G134356

Source:

HEK 293 Cells

Tag:

DDK,N-terminus

Endotoxin Level:

Less than 0.06 EU/µg protein (determined by LAL method).

Molecular Weight:

~17 kDa (SDS-PAGE)

Price:

50 µg/$491

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Human TNFSF18 / GITRL Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89331

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20.31 kDa

Price:

20 µg/$150

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Human TNFSF18 / GITRL Protein (Recombinant 6His, C-terminus) (Glu74-Ser199) - LS-G139592

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

15.3 kDa

Price:

10 µg/$288; 50 µg/$436

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Human TNFSF18 / GITRL Protein (Recombinant GST) (Full Length) - LS-G31431

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

46.7 kDa

Price:

10 µg/$479; 25 µg/$670

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Human TNFSF18 / GITRL Protein (Recombinant GST, N-terminus) (aa68-177) - LS-G60950

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TNFSF18 / GITRL Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71260

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.5 kDa

Price:

20 µg/$1,107

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TNFSF18 / GITRL Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100455

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20.31 kDa

Price:

100 µg/$494

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Mouse TNFSF18 / GITRL Protein (Recombinant DDK (Flag)) (aa45-173) - LS-G3721

Source:

HEK 293 Cells

Tag:

DDK (Flag)

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

~22kDa (SDS-PAGE)

Price:

50 µg/$414

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Human TNFSF18 / GITRL Protein (Recombinant) (aa74-199) - LS-G5779

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

14.3 kDa

Price:

5 µg/$282; 100 µg/$1,466; 500 µg/$3,025

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Human TNFSF18 / GITRL Protein (Recombinant His) - LS-G3302

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human TNFSF18 / GITRL Protein (Recombinant) - LS-G1470

Source:

E. coli

Tag:

None

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

Select

Human TNFSF18 / GITRL Protein (Recombinant) - LS-G346

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

14.4 kDa

Price:

5 µg/$268; 20 µg/$349

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Human TNFSF18 / GITRL Protein (Recombinant) - LS-G131374

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

~14.2 kDa

Price:

30 µg/$291; 200 µg/$769; 1 mg/$2,851

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Human TNFSF18 / GITRL Protein (Recombinant 6His, C-terminus) (Glu74-Ser199) - LS-G39874

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

15.3kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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Human TNFSF18 / GITRL Protein (Recombinant Human IgG1 Fc, C-terminus) (Glu74-Ser199) - LS-G145568

Source:

HEK 293 Cells

Tag:

Human IgG1 Fc, C-terminus

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

50 kDa

Price:

100 µg/$423; 1 mg/$1,717

Select

Human TNFSF18 / GITRL Protein (Recombinant) - LS-G137671

Source:

HEK 293 Cells

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1 EU/µg (determined by LAL method).

Molecular Weight:

The 147 amino acid recombinant protein has a predicted molecular mass of approximately 16.5 kD. The protein migrates at about 25 kD in DTT-reducing conditions by SDS-PAGE. The predicted N-terminal amino acid is His.

Price:

10 µg/$306; 25 µg/$390; 100 µg/$938

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