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TNFSF13 / APRIL
tumor necrosis factor (ligand) superfamily, member 13
TNFSF13 is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
| Gene Name: | tumor necrosis factor (ligand) superfamily, member 13 |
| Family/Subfamily: | TNF , not assigned-TNF |
| Synonyms: | TNFSF13, APRIL, CD256, CD256 antigen, TALL-2, TALL2, ZTNF2, TNF-related death ligand 1, TRDL-1, UNQ383/PRO715 |
| Target Sequences: | NM_003808 NP_003799.1 O75888 |
Publications (3)
1
Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia. Robak OH, Heimesaat MM, Kruglov AA, Prepens S, Ninnemann J, Gutbier B, Reppe K, Hochrein H, Suter M, Kirschning CJ, Marathe V, Buer J, Hornef MW, Schnare M, Schneider P, Witzenrath M, Bereswill S, Steinhoff U, Suttorp N, Sander LE, Chaput C, Opitz B. The Journal of clinical investigation. 2018 August;128:3535-3545. [Full Text Article]
[PubMed:29771684]
[PMC:PMC6063483]
2
Soluble a-proliferation-inducing ligand (sAPRIL), a novel serum biomarker predicting the recurrence and metastasis of pancreatic adenocarcinoma after surgery. Han L, Zhang W, Song F, Guo Y, Guo K, Zhou W. Molecular medicine reports. 2014 October;10:1978-1984. [Full Text Article]
[PubMed:25110120]
3
Development and characterization of APRIL antagonistic monoclonal antibodies for treatment of B-cell lymphomas. Guadagnoli M, Kimberley FC, Phan U, Cameron K, Vink PM, Rodermond H, Eldering E, Kater AP, van Eenennaam H, Medema JP. Blood. 2011 Jun;117:6856-65. [Full Text Article]
[PubMed:21543761]
Related Antibodies: LS-C18659, LS-C18687, LS-C18658.
☰ Filters
Products
Proteins
(27)
Type
Over-Expression Lysate
(6)
Recombinant
(21)
Target
TNFSF13 / APRIL
(27)
Application
SDS-PAGE
(1)
Publications
No
(27)
Tag
DDK (Flag)-Human ACRP30headless aa 16-108
(2)
DDK (Flag)-Human ACRP30headless aa 18-110
(2)
Fc, N-terminus
(2)
Flag-His, N-terminus
(1)
GST
(1)
His
(4)
His, N-Terminal
(1)
His-Flag, C-terminus
(1)
His-S
(1)
His-T7
(1)
Human IgG1 Fc, N-terminus
(1)
Myc-DDK (Flag)
(6)
Species
Bovine
(1)
Dog
(1)
Human
(11)
Mouse
(9)
Rat
(1)
Rhesus monkey
(1)
Source
293T Cells
(3)
E. coli
(10)
HEK 293 Cells
(8)
High Five Cells
(1)
Mammalian Cells
(4)
Wheat Germ Extract
(1)
Purification
Purified
(5)
Low Endotoxin Level
Low endotoxin level
(13)
Biologically Active
Biologically active
(3)
High Five Cells
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
16.3 kDa
2 µg/$268; 10 µg/$349
E. coli
His
19.4 kDa
10 µg/$295; 50 µg/$532; 100 µg/$850; 200 µg/$1,049; 1 mg/$2,215; 500 µg/$1,733; 5 mg/$3,711; 2 mg/$2,407
Mammalian Cells
Fc, N-terminus
Less than 0.1 ng/mL (Less than 1 EU/µg) (determined by LAL method).
10 µg/$277; 50 µg/$395; 500 µg/$1,377; 1 mg/$1,765
Wheat Germ Extract
GST
52.91 kDa
10 µg/$479; 25 µg/$670
Mammalian Cells
Flag-His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
50 kDa
10 µg/$376; 50 µg/$475
HEK 293 Cells
DDK (Flag)-Human ACRP30headless aa 16-108
Less than 0.01 EU/µg protein (determined by LAL method).
~34kDa (SDS-PAGE)
10 µg/$428
E. coli
His-S
23.8 kDa
10 µg/$297; 50 µg/$542; 100 µg/$865; 200 µg/$1,065; 1 mg/$2,239; 500 µg/$1,755; 5 mg/$3,781; 2 mg/$2,430
E. coli
His, N-Terminal
17.9 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
Mammalian Cells
His-Flag, C-terminus
Less than 0.1 ng/mL (Less than 1 EU/µg) (determined by LAL method).
10 µg/$288; 50 µg/$376; 500 µg/$1,815; 1 mg/$2,573
HEK 293 Cells
Myc-DDK (Flag)
26.9 kDa
100 µg/$494
HEK 293 Cells
Myc-DDK (Flag)
22.9 kDa
100 µg/$494
E. coli
None
100 µg/$361; 500 µg/$739; 20 µg/$261
E. coli
His-T7
20.3 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
21.9 kDa (SDS-PAGE)
50 µg/$355; 10 µg/$278; 1 mg/$1,612
HEK 293 Cells
Human IgG1 Fc, N-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant mouse TNFSF13/Fc comprises 405 amino acids and has a predicted molecular mass of 44.8 kDa. The apparent molecular mass of the protein is approximately 47 kDa in SDS-PAGE under reducing conditions due to glycosylation.
50 µg/$364; 1 mg/$2,031
293T Cells
Myc-DDK (Flag)
27.3 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
26.9 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
22.9 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
27.3 kDa
100 µg/$494
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
21.9 kDa
5 µg/$268; 20 µg/$349
E. coli
145 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
16.06 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
HEK 293 Cells
DDK (Flag)-Human ACRP30headless aa 18-110
Less than 0.01 EU/µg protein (determined by LAL method).
10 µg/$428
HEK 293 Cells
DDK (Flag)-Human ACRP30headless aa 18-110
Less than 0.02 EU/µg protein (determined by LAL method).
10 µg/$428
HEK 293 Cells
DDK (Flag)-Human ACRP30headless aa 16-108
Less than 0.01 EU/µg protein (determined by LAL method).
~34kDa (SDS-PAGE)
10 µg/$435
Mammalian Cells
Fc, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.7 kDa
10 µg/$277; 50 µg/$389
Viewing 1-25
of 27
product results
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