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TNFSF12 / TWEAK

tumor necrosis factor (ligand) superfamily, member 12

TNFSF12 / TWEAK is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.

Gene Name: tumor necrosis factor (ligand) superfamily, member 12
Family/Subfamily: TNF , not assigned-TNF
Synonyms: TNFSF12, APO3/DR3 ligand, APO3L, DR3LG, APO3 ligand, TWEAK
Target Sequences: NM_003809 NP_003800.1 O43508

Publications (1)

1
Comparative transcriptome analysis of human and murine choroidal neovascularization identifies fibroblast growth factor inducible-14 as phylogenetically conserved mediator of neovascular age-related macular degeneration. Julian Wolf, Anja Schlecht, Dennis-Dominik Rosmus, Stefaniya Boneva, Hansjürgen Agostini, Günther Schlunck, Peter Wieghofer, Clemens Lange. Biochimica et biophysica acta. Molecular basis of disease. 2022 April;1868:166340. [Full Text Article] [PubMed:35032596]

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ELISA Kits (24)
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TNFSF12 / TWEAK (24)
Human (13)
Mouse (7)
Rat (5)
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96-Well Microplate (6)
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Cell Culture Supernatants (8)
Cell Lysates (3)
Cell Supernatant (1)
Plasma (21)
Serum (21)
Tissue Homogenates (7)
TNFSF12 / TWEAK ELISA Kit
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Sandwich
96-Well Microplate
Rat
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$795
TNFSF12 / TWEAK ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.274 - 200 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$840
TNFSF12 / TWEAK ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
TNFSF12 / TWEAK ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
TNFSF12 / TWEAK ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
TNFSF12 / TWEAK ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
TNFSF12 / TWEAK ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Human
8 - 500 pg/ml
Chemiluminescent
Cell Lysates, Plasma, Serum
1 Plate/$649
TNFSF12 / TWEAK ELISA Kit
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Development Kit
1000 Wells
Human
16 - 2000 pg/ml
Colorimetric - 405nm (ABTS)
1 Test/$540
TNFSF12 / TWEAK ELISA Kit
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Sandwich
96-Well Microplate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$795
TNFSF12 / TWEAK ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
TNFSF12 / TWEAK ELISA Kit
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Sandwich
96-Well Microplate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$795
TNFSF12 / TWEAK ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$717
TNFSF12 / TWEAK ELISA Kit
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Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$669
TNFSF12 / TWEAK ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$717
TNFSF12 / TWEAK ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
250 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
TNFSF12 / TWEAK ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
TNFSF12 / TWEAK ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$958
TNFSF12 / TWEAK ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$958
TNFSF12 / TWEAK ELISA Kit
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Sandwich
96-Well Strip Plate
Human
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Supernatant, Plasma, Serum
1 Plate/$598
TNFSF12 / TWEAK ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$834
TNFSF12 / TWEAK ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$893
TNFSF12 / TWEAK ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
TNFSF12 / TWEAK ELISA Kit
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Sandwich
12 x 8-Well Microstrips
Human
16 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$479
TNFSF12 / TWEAK ELISA Kit
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Sandwich
96-Well Microplate
Human
46.88 - 1500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$588
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).