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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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TNFSF12 / TWEAK
tumor necrosis factor (ligand) superfamily, member 12
TNFSF12 / TWEAK is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
| Gene Name: | tumor necrosis factor (ligand) superfamily, member 12 |
| Family/Subfamily: | TNF , not assigned-TNF |
| Synonyms: | TNFSF12, APO3/DR3 ligand, APO3L, DR3LG, APO3 ligand, TWEAK |
| Target Sequences: | NM_003809 NP_003800.1 O43508 |
Publications (1)
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