TNFSF11 / RANKL / TRANCE

tumor necrosis factor (ligand) superfamily, member 11

TNFSF11 / RANKL / TRANCE is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

☰ Filters

Products

Proteins (35)

Type

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (5)

Recombinant (29)

Target

TNFSF11 / RANKL / TRANCE (35)

Format

Animal-free (1)

Publications

No (35)

Tag

6His, C-terminus (2)

6His, N-terminus (5)

6His-SUMO, N-terminus (1)

DDK (Flag) (1)

GST (1)

GST, N-terminus (1)

His (2)

His, N-Terminal (1)

His-GST (1)

His-T7 (2)

Human IgG1 Fc (1)

Myc-DDK (Flag) (6)

more less

Species

Human (21)

Mouse (10)

Rat (2)

Source

293F Cells (1)

293T Cells (2)

E. coli (16)

HEK 293 Cells (9)

Human (1)

Human Cells (2)

Insect Cells (1)

Mammalian Cells (1)

Wheat Germ Extract (2)

Purification

Purified (10)

Low Endotoxin Level

Low endotoxin level (18)

Biologically Active

Biologically active (7)

Animal-free

Animal-free (1)

Select

Human TNFSF11 / RANKL / TRANCE Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67579

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.5 kDa

Price:

20 µg/$1,107

Select

Human TNFSF11 / RANKL / TRANCE Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67578

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.3 kDa

Price:

20 µg/$1,107

Select

Human TNFSF11 / RANKL / TRANCE Protein (Recombinant GST, N-terminus) (aa222-316) - LS-G60791

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Mouse TNFSF11 / RANKL / TRANCE Protein (Recombinant) (Gln137-Asp316) - LS-G40313

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

20.1kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353

Select

Human TNFSF11 / RANKL / TRANCE Protein (Recombinant) (aa31-401) - LS-G55920

Source:

Human

Tag:

None

Molecular Weight:

42.4kDa

Price:

50 µg/$702; 10 µg/$323; 200 µg/$1,298; 100 µg/$1,096; 1 mg/$2,562; 500 µg/$2,060; 5 mg/$4,901; 2 mg/$2,753

Select

Mouse TNFSF11 / RANKL / TRANCE Protein (Recombinant 6His-SUMO, N-terminus) (aa70-316) - LS-G56589

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

Select

Human TNFSF11 / RANKL / TRANCE Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80205

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.5 kDa

Price:

20 µg/$150

Select

Human TNFSF11 / RANKL / TRANCE Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80206

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.3 kDa

Price:

20 µg/$150

Select

Mouse TNFSF11 / RANKL / TRANCE Protein (Recombinant His-GST) (aa92-263) - LS-G13000

Source:

E. coli

Tag:

His-GST

Molecular Weight:

51.7 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

Select

Human TNFSF11 / RANKL / TRANCE Protein (Recombinant His-T7) (aa79-247) - LS-G13001

Source:

E. coli

Tag:

His-T7

Molecular Weight:

23.1 kDa

Price:

10 µg/$339; 50 µg/$802; 100 µg/$1,214; 200 µg/$1,430; 1 mg/$2,728; 500 µg/$2,223; 5 mg/$5,601; 2 mg/$2,988

Select

Rat TNFSF11 / RANKL / TRANCE Protein (Recombinant His-T7) (aa106-240) - LS-G13005

Source:

E. coli

Tag:

His-T7

Molecular Weight:

19.0 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

Select

Human TNFSF11 / RANKL / TRANCE Protein (Recombinant GST) (Full Length) - LS-G31227

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

54.1 kDa

Price:

10 µg/$479; 25 µg/$670

Select

Human TNFSF11 / RANKL / TRANCE Protein (Over-Expression Lysate 6His, N-terminus) (Ile140-Asp317) - LS-G26676

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

22.4 kDa

Price:

100 µg/$298

Select

Human TNFSF11 / RANKL / TRANCE Protein (Over-Expression Cell Culture Supernatant 6His, N-terminus) (Ile140-Asp317) - LS-G26826

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

22.4 kDa

Price:

200 µl/$283

Select

Human TNFSF11 / RANKL / TRANCE Protein (Recombinant 6His, N-terminus) (Ile140-Asp317) - LS-G40118

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

22.4kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157

Select

Mouse TNFSF11 / RANKL / TRANCE Protein (Recombinant 6His, C-terminus) (Ala73-Asp316) - LS-G40052

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

28.5kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353

Select

TNFSF11 / RANKL / TRANCE Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100104

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.3 kDa

Price:

100 µg/$494

Select

Mouse TNFSF11 / RANKL / TRANCE Protein (Recombinant) - LS-G137701

Source:

Insect Cells

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.01 ng/µg (determined by LAL method).

Molecular Weight:

The 178 amino acid recombinant protein has a predicted molecular mass of approximately 20 kD. The DTT-reduced protein migrates at approximately 20 kD by SDS-PAGE.

Price:

10 µg/$363

Select

Human TNFSF11 / RANKL / TRANCE Protein (Recombinant) - LS-G137720

Source:

HEK 293 Cells

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.01 ng/µg (determined by LAL method).

Molecular Weight:

The 203 amino acid recombinant protein has a predicted molecular mass of approximately 22.7 kD. The DTT-reduced and non-reduced protein migrate at approximately 36-40 kD by SDS-PAGE. The N-terminal amino acid is His.

Price:

10 µg/$355; 25 µg/$493; 100 µg/$1,182; 500 µg/$2,793

Select

Human TNFSF11 / RANKL / TRANCE Protein (Recombinant 6His, N-terminus) (Ile140-Asp317) - LS-G140368

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

22.4 kDa

Price:

20 µg/$360; 100 µg/$728

Select

Mouse TNFSF11 / RANKL / TRANCE Protein (Recombinant 6His, C-terminus) (Ala73-Asp316) - LS-G140666

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

28.5 kDa

Price:

10 µg/$317; 50 µg/$524

Select

Mouse TNFSF11 / RANKL / TRANCE Protein (Recombinant) (Gln137-Asp316) - LS-G140667

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

20.1 kDa

Price:

10 µg/$317; 50 µg/$524

Select

Mouse TNFSF11 / RANKL / TRANCE Protein (Recombinant His, N-Terminal) - LS-G132939

Source:

293F Cells

Tag:

His, N-Terminal

Molecular Weight:

35kDa

Price:

10 µg/$331; 50 µg/$752; 200 µg/$1,365; 100 µg/$1,156; 1 mg/$2,648; 500 µg/$2,144; 5 mg/$5,251; 2 mg/$2,838

Select

Human TNFSF11 / RANKL / TRANCE Protein (Recombinant His) (aa77-194) - LS-G141105

Source:

E. coli

Sequence Length:

117 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

12.98 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

Select

Human TNFSF11 / RANKL / TRANCE Protein (Recombinant 6His, N-terminus) - LS-G136728

Source:

E. coli

Tag:

6His, N-terminus

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

22.4 kDa

Price:

50 µg/$698; 10 µg/$356; 1 mg/$2,837; 500 µg/$1,987

Viewing 1-25 of 35 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.