TNFSF10 / TRAIL

tumor necrosis factor (ligand) superfamily, member 10

TNFSF10 / TRAIL is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Products

Proteins (28)

Type

Over-Expression Lysate (2)

Recombinant (26)

Target

TNFSF10 / TRAIL (28)

Publications

No (28)

Tag

6His, C-terminus (2)

DDK (Flag) (1)

GST (1)

His (2)

His, N-Terminal (1)

His-GST, N-terminus (1)

His-Linker Peptide (3)

His-S (1)

His-T7 (1)

Isoleucine Zipper Motif (1)

Myc-DDK (Flag) (2)

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Species

Dog (1)

Human (21)

Mouse (4)

Rat (1)

Source

293T Cells (1)

E. coli (24)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (13)

Low Endotoxin Level

Low endotoxin level (17)

Biologically Active

Biologically active (7)

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Rat TNFSF10 / TRAIL Protein (Recombinant His-GST, N-terminus) (Pro115-Ala287) - LS-G11662

Source:

E. coli

Tag:

His-GST, N-terminus

Molecular Weight:

52.0 kDa

Price:

10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257

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Human TNFSF10 / TRAIL Protein (Recombinant Isoleucine Zipper Motif) (aa95-281) - LS-G3910

Source:

E. coli

Tag:

Isoleucine Zipper Motif

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.01 EU/µg protein (determined by LAL method).

Molecular Weight:

28kDa-82kDa

Price:

10 µg/$337

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Human TNFSF10 / TRAIL Protein (Recombinant His) (aa39-281) - LS-G21275

Source:

E. coli

Tag:

His

Molecular Weight:

32.5 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human TNFSF10 / TRAIL Protein (Recombinant 6His, C-terminus) (Val114-Gly281) - LS-G138632

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

20.6 kDa

Price:

10 µg/$244; 50 µg/$288

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Dog TNFSF10 / TRAIL Protein (Recombinant His-T7) (aa36-281) - LS-G23930

Source:

E. coli

Tag:

His-T7

Molecular Weight:

32.6 kDa

Price:

10 µg/$299; 50 µg/$552; 100 µg/$882; 200 µg/$1,080; 1 mg/$2,261; 500 µg/$1,775; 5 mg/$3,851; 2 mg/$2,453

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Mouse TNFSF10 / TRAIL Protein (Recombinant His-S) (aa40-291) - LS-G11664

Source:

E. coli

Tag:

His-S

Molecular Weight:

35.9 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human TNFSF10 / TRAIL Protein (Recombinant) - LS-G332

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

19.6 kDa

Price:

10 µg/$268; 50 µg/$349

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Mouse TNFSF10 / TRAIL Protein (Recombinant) - LS-G373

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

20.0 kDa

Price:

10 µg/$268; 50 µg/$349

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Mouse TNFSF10 / TRAIL Protein (Recombinant) - LS-G145612

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.2 EU/µg protein (determined by LAL method).

Molecular Weight:

20 kDa

Price:

1 mg/$1,058; 10 µg/$253; 50 µg/$300

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Human TNFSF10 / TRAIL Protein (Recombinant) - LS-G143817

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

19.5 kDa

Price:

100 µg/$677

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TNFSF10 / TRAIL Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117068

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.3 kDa

Price:

100 µg/$494

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Human TNFSF10 / TRAIL Protein (Recombinant GST) (Full Length) - LS-G31310

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

56.65 kDa

Price:

10 µg/$479; 25 µg/$670

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Human TNFSF10 / TRAIL Protein (Recombinant) - LS-G27196

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.2 EU/µg protein (determined by LAL method).

Molecular Weight:

19.6 kDa (SDS-PAGE)

Price:

50 µg/$296; 10 µg/$253; 1 mg/$893

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Human TNFSF10 / TRAIL Protein (Recombinant) - LS-G37727

Tag:

None

Molecular Weight:

19.6 kD

Price:

50 µg/$538

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Human TNFSF10 / TRAIL Protein (Recombinant) (Val114-Gly281) - LS-G97969

Source:

E. coli

Tag:

None

Molecular Weight:

19.6 kDa

Price:

100 µg/$713; 1 mg/$3,773

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Human TNFSF10 / TRAIL Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79198

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.3 kDa

Price:

20 µg/$150

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Human TNFSF10 / TRAIL Protein (Recombinant His-Linker Peptide) (aa95-281) - LS-G3985

Source:

E. coli

Tag:

His-Linker Peptide

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.01 EU/µg protein (determined by LAL method).

Price:

50 µg/$498

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Human TNFSF10 / TRAIL Protein (Recombinant His-Linker Peptide) (aa95-281) - LS-G3988

Source:

E. coli

Tag:

His-Linker Peptide

Endotoxin Level:

Less than 0.01 EU/µg protein (determined by LAL method).

Price:

20 µg/$470

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Human TNFSF10 / TRAIL Protein (Recombinant) - LS-G131378

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

~19.5 kDa

Price:

10 µg/$386

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Human TNFSF10 / TRAIL Protein (Recombinant DDK (Flag)) (aa95-281) - LS-G3871

Source:

E. coli

Tag:

DDK (Flag)

Endotoxin Level:

Less than 0.01 EU/µg protein (determined by LAL method).

Molecular Weight:

~23kDa (SDS-PAGE)

Price:

10 µg/$260

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Mouse TNFSF10 / TRAIL Protein (Recombinant His-Linker Peptide) (aa99-291) - LS-G3987

Source:

E. coli

Tag:

His-Linker Peptide

Endotoxin Level:

Less than 0.01 EU/µg protein (determined by LAL method).

Molecular Weight:

~24kDa

Price:

20 µg/$491

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Human TNFSF10 / TRAIL Protein (Recombinant 6His, C-terminus) (Val114-Gly281) - LS-G39780

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

20.6kD

Price:

10 µg/$243; 50 µg/$288; 500 µg/$1,262; 1 mg/$1,627

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Human TNFSF10 / TRAIL Protein (Recombinant) - LS-G136732

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

19.5 kDa

Price:

50 µg/$346; 10 µg/$259; 1 mg/$1,294; 500 µg/$977

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Human TNFSF10 / TRAIL Protein (Recombinant) (Arg115-Gly281) - LS-G38571

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

19.5kD

Price:

10 µg/$248; 50 µg/$313; 500 µg/$743; 1 mg/$1,048

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Human TNFSF10 / TRAIL Protein (Recombinant) - LS-G3585

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Price:

100 µg/$317; 500 µg/$526; 20 µg/$245

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