TNFRSF21 / DR6

tumor necrosis factor receptor superfamily, member 21

Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.

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Products

Proteins (24)

Type

Over-Expression Lysate (2)

Recombinant (22)

Target

TNFRSF21 / DR6 (24)

Application

Bind (3)

ELISA (2)

Func (2)

SDS-PAGE (4)

Publications

No (24)

Tag

6His, C-terminus (3)

6His, N-terminus (1)

Fc (1)

Fc, C-terminus (2)

Fc-6His, C-terminus (1)

GST (2)

His (4)

His,C-terminus (3)

His-SUMO (1)

Human IgG Fc, C-terminus (1)

Human IgG1 Fc (2)

Myc-DDK (Flag) (2)

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Species

Human (17)

Mouse (6)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (7)

Human Cells (7)

Mammalian Cells (3)

Wheat Germ Extract (2)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (16)

Biologically Active

Biologically active (2)

Select

Mouse TNFRSF21 / DR6 Protein (Recombinant Human IgG1 Fc) (aa42-348) - LS-G3906

Source:

HEK 293 Cells

Tag:

Human IgG1 Fc

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

~80kDa (SDS-PAGE)

Price:

50 µg/$309

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Mouse TNFRSF21 / DR6 Protein (Recombinant Fc-6His, C-terminus) (Gln42-His349) - LS-G39513

Source:

Human Cells

Tag:

Fc-6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

64.7kD

Price:

10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

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Human TNFRSF21 / DR6 Protein (Recombinant His,C-terminus) (Met1-Leu350) - LS-G48541

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human DR6 consists of 315 amino acids and predicts a molecular mass of 34.2 kDa. By SDS-PAGE under reducing conditions, the apparent molecular mass of rhDR6 is approximately 55-60 kDa due to the glycosylation.

Price:

100 µg/$480

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Human TNFRSF21 / DR6 Protein (Recombinant Human IgG Fc, C-terminus) (Met1-Leu350) - LS-G48547

Source:

HEK 293 Cells

Tag:

Human IgG Fc, C-terminus

Application:

Bind ELISA Func SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human DR6/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 547 amino acids and predicts a molecular mass of 60.3 kDa. By SDS-PAGE under reducing conditions, the apparent molecular mass of rhDR6/Fc monomer is approximately 95-100 kDa due to the glycosylation.

Price:

100 µg/$364; 1 mg/$1,452

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Human TNFRSF21 / DR6 Protein (Recombinant His,C-terminus) (Met1-Leu350) - LS-G48552

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

Bind ELISA Func SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human DR6 consists of 320 amino acids and predicts a molecular mass of 35 kDa. By SDS-PAGE under reducing conditions, the apparent molecular mass of rh DR6 is approximately 50-60 kDa due to the glycosylation.

Price:

100 µg/$441; 1 mg/$2,003

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Mouse TNFRSF21 / DR6 Protein (Recombinant His,C-terminus) (Met1-His349) - LS-G49359

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

Bind SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The secreted recombinant mouse TNFRSF21 comprises 319 amino acids and has a predicted molecular mass of 35 kDa. As a result of glycosylation, it migrates as an approximately 55-60 kDa band in SDS-PAGE under reducing conditions.

Price:

100 µg/$441; 1 mg/$2,003

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Human TNFRSF21 / DR6 Protein (Recombinant Fc, C-terminus) (Gln42-Leu350) - LS-G39707

Source:

Human Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

61.7kD

Price:

10 µg/$255; 50 µg/$343; 500 µg/$1,585; 1 mg/$2,157

Select

Human TNFRSF21 / DR6 Protein (Recombinant 6His, C-terminus) (Gln42-Leu350) - LS-G38856

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

34.62kD

Price:

10 µg/$240; 50 µg/$299; 500 µg/$929; 1 mg/$1,245

Select

Human TNFRSF21 / DR6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89974

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71.84 kDa

Price:

20 µg/$150

Select

Human TNFRSF21 / DR6 Protein (Recombinant) (Met1-Leu350) - LS-G97396

Source:

Human Cells

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

34.2 kDa

Price:

100 µg/$926

Select

Human TNFRSF21 / DR6 Protein (Recombinant Fc) (Met1-Leu350) - LS-G97397

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

60.3 kDa

Price:

100 µg/$502

Select

Human TNFRSF21 / DR6 Protein (Recombinant His) (Met1-Leu350) - LS-G97395

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

35 kDa

Price:

100 µg/$793; 1 mg/$4,191

Select

Human TNFRSF21 / DR6 Protein (Recombinant His) (aa420-568) - LS-G15396

Source:

E. coli

Tag:

His

Molecular Weight:

17.6 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Mouse TNFRSF21 / DR6 Protein (Recombinant His) (aa406-605) - LS-G15398

Source:

E. coli

Tag:

His

Molecular Weight:

23.7 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human TNFRSF21 / DR6 Protein (Recombinant His-SUMO) (aa371-655) - LS-G21274

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

47.95 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

Select

Human TNFRSF21 / DR6 Protein (Recombinant GST) (Full Length) - LS-G33303

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

39.38 kDa

Price:

10 µg/$479; 25 µg/$670

Select

Human TNFRSF21 / DR6 Protein (Recombinant GST) (Full Length) - LS-G33304

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

77.66 kDa

Price:

10 µg/$479; 25 µg/$670

Select

Human TNFRSF21 / DR6 Protein (Recombinant 6His, N-terminus) (Gln42-His349) - LS-G26556

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

35.8 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365; 200 µg/$484

Select

TNFRSF21 / DR6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101220

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71.84 kDa

Price:

100 µg/$494

Select

Mouse TNFRSF21 / DR6 Protein (Recombinant 6His, C-terminus) (Gln42-His349) - LS-G139307

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

64.7 kDa

Price:

10 µg/$281; 50 µg/$389

Select

Human TNFRSF21 / DR6 Protein (Recombinant 6His, C-terminus) (Gln42-Leu350) - LS-G138664

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

34.6 kDa

Price:

10 µg/$240; 50 µg/$299

Select

Human TNFRSF21 / DR6 Protein (Recombinant Fc, C-terminus) (Gln42-Leu350) - LS-G138824

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

61.7 kDa

Price:

10 µg/$255; 50 µg/$339

Select

Human TNFRSF21 / DR6 Protein (Recombinant Human IgG1 Fc) (aa42-351) - LS-G3874

Source:

HEK 293 Cells

Tag:

Human IgG1 Fc

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

~80kDa (SDS-PAGE)

Price:

50 µg/$309

Select

Mouse TNFRSF21 / DR6 Protein (Recombinant His) (Met1-His349) - LS-G98863

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

35 kDa

Price:

100 µg/$721

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