TNFRSF21 / DR6

tumor necrosis factor receptor superfamily, member 21

Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.

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ELISA Kits (2)

Type

Custom (1)

Sandwich (1)

Target

TNFRSF21 / DR6 (2)

Reactivity

Human (2)

Format

96-Well Microplate (1)

Publications

No (2)

Sample Type

Cell Culture Supernatants (1)

Citrate Plasma (1)

EDTA Plasma (1)

Heparin Plasma (1)

Serum (1)

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Human TNFRSF21 / DR6 (Sandwich ELISA) ELISA Kit - LS-F57148

Type:

Sandwich

Reactivity:

Human

Range:

312 - 20000 pg/ml

Sample Types:

Cell Culture Supernatants, Citrate Plasma, EDTA Plasma, Heparin Plasma, Serum

Price:

1 Plate/$1,150

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Human TNFRSF21 / DR6 (Custom ELISA) ELISA Kit - LS-F341

Type:

Custom

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$672

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