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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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TNFRSF21 / DR6

tumor necrosis factor receptor superfamily, member 21

Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.

Gene Name: tumor necrosis factor receptor superfamily, member 21
Family/Subfamily: TNF Receptor , not assigned-TNF Receptor
Synonyms: TNFRSF21, CD358 antigen, BM-018, DR6, TNFR-related death receptor 6, CD358, Death receptor 6
Target Sequences: NM_014452 NP_055267.1 O75509

Viewing 1-25 of 72 items
TNFRSF21 / DR6 Antibody - Anti-TNFRSF21 / DR6 antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:75.
Select
Rabbit Polyclonal to Human TNFRSF21 / DR6
Human
IHC, IHC-P, WB
Unconjugated
200µl   $425.00
TNFRSF21 / DR6 Antibody - Human Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal to Mouse TNFRSF21 / DR6
Mouse, Rat, Human
IHC-P, WB
Unconjugated
100µl   0.5mg/ml   $425.00
Select
Rabbit Polyclonal (IgG) to Rat TNFRSF21 / DR6
Mouse, Rat, Human
WB
Unconjugated
100µg   0.5mg/ml   $495.00
Select
Mouse Monoclonal [clone DR-6-04-EC] (IgG1) to Human TNFRSF21 / DR6
Human
Flo, IP
Unconjugated
0.2mg   $415.00
TNFRSF21 / DR6 Antibody - Western blot of DR6 in K562 (1,3) and Raji (2,4) whole cell lysate in the absence (1,2) or presence (3,4) of blocking peptide (Catalog no. 2157P) with DR6 antibody at 1:500 dilution.
Select
Rabbit Polyclonal (IgG) to Human TNFRSF21 / DR6
Human
ELISA, WB
Unconjugated
0.1mg   1mg/ml   $375.00
Select
Rat Monoclonal (IgG2a) to Human TNFRSF21 / DR6
Human
Flo
Unconjugated
100µg   1mg/ml   $415.00
Select
Rabbit Polyclonal (IgG) to Human TNFRSF21 / DR6
Human
ICC, WB
Unconjugated
100µg   $605.00
TNFRSF21 / DR6 Antibody - Detection limit for recombinant GST tagged TNFRSF21 is 0.1 ng/ml as a capture antibody.
Select
Mouse Monoclonal [clone 1B1] (IgG1,k) to Human TNFRSF21 / DR6
Human
ELISA
Unconjugated
100µg   $365.00
Select
Mouse Polyclonal (IgG) to Human TNFRSF21 / DR6
Human
WB
Unconjugated
50µg   $560.00
Select
Rabbit Polyclonal to Rat TNFRSF21 / DR6
Mouse, Rat, Human
WB
Unconjugated
30µg   0.5mg/ml   $245.00; 100µg   0.5mg/ml   $405.00
TNFRSF21 / DR6 Antibody - Immunohistochemistry of paraffin-embedded human pancreas using antibody at 1:100 dilution.
Select
Rabbit Polyclonal (IgG) to Human TNFRSF21 / DR6
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl   $285.00; 100µl   $385.00
Select
Mouse Monoclonal (IgG1) to Human TNFRSF21 / DR6
Human
Flo, ICC, IP
Unconjugated
100µg   $560.00
TNFRSF21 / DR6 Antibody - DR6 Antibody in Flow Cytometry (Flow)
Select
Mouse Monoclonal [clone DR-6-04-EC] (IgG1) to Human TNFRSF21 / DR6
Human
Flo, ICC, IP
Unconjugated
100µg   1mg/ml   $425.00
TNFRSF21 / DR6 Antibody - 1:100 staining human thyroid carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
Rabbit Polyclonal (IgG) to Human TNFRSF21 / DR6
Mouse, Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Mouse Monoclonal [clone DR-6-04-EC] (IgG1) to Human TNFRSF21 / DR6
Human
Flo, ICC, IP
FITC Conjugated
0.1mg   1mg/ml   $345.00
Select
Mouse Monoclonal [clone DR-6-04-EC] (IgG1) to Human TNFRSF21 / DR6
Human
Flo, IP
Unconjugated, Concentrated
100µg   $495.00
TNFRSF21 / DR6 Antibody - Western blot analysis of extracts of various cell lines.
Select
Rabbit Polyclonal (IgG) to Human TNFRSF21 / DR6
Mouse, Rat, Human
IHC, WB
Unconjugated
20µl   $215.00; 50µl   $235.00; 100µl   $315.00; 200µl   $425.00
Select
Rabbit Polyclonal (IgG) to Human TNFRSF21 / DR6
Human
ELISA, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human TNFRSF21 / DR6
Human
ELISA, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human TNFRSF21 / DR6
Human
ELISA, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human TNFRSF21 / DR6
Human
ELISA, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human TNFRSF21 / DR6
Human
ELISA, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal to Human TNFRSF21 / DR6
Human
ELISA, WB
Unconjugated
50µl   $235.00; 100µl   $275.00; 200µl   $305.00
Select
Rabbit Polyclonal to Human TNFRSF21 / DR6
Mouse, Human
ELISA, WB
Unconjugated
100µg   100µl   1µg/µl   $305.00
TNFRSF21 / DR6 Antibody - Western blot analysis of Human fetal brain tissue, using TNFRSF21 Polyclonal Antibody at dilution of 1:420.
Select
Rabbit Polyclonal (IgG) to Human TNFRSF21 / DR6
Human
ELISA, WB
Unconjugated
20µl   0.3mg/ml   $205.00; 60µl   0.3mg/ml   $235.00; 120µl   0.3mg/ml   $295.00; 200µl   0.3mg/ml   $395.00

Viewing 1-25 of 72 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).