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TNFRSF18 / GITR

tumor necrosis factor receptor superfamily, member 18

TNFRSF18 / GITR is a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Gene Name: tumor necrosis factor receptor superfamily, member 18
Family/Subfamily: TNF Receptor , not assigned-TNF Receptor
Synonyms: TNFRSF18, AITR, CD357, CD357 antigen, GITR, GITR-D
Target Sequences: NM_004195 NP_004186.1 Q9Y5U5

Publications (1)

1
Human glucocorticoid-induced TNF receptor ligand regulates its signaling activity through multiple oligomerization states. Zhou Z, Song X, Berezov A, Zhang G, Li Y, Zhang H, Murali R, Li B, Greene MI. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:5465-70. [PubMed:18378892] [PMC:PMC2291095] Related Antibodies: LS-C41004.

☰ Filters
Products
Proteins (15)
Over-Expression Lysate (4)
Recombinant (11)
TNFRSF18 / GITR (15)
No (15)
Fc (1)
Fc, C-terminus (2)
Fc/6His,C-terminus (1)
Fc-6His, C-terminus (1)
GST (1)
GST, N-terminus (1)
Human IgG1 Fc (2)
mFc, C-terminus (1)
Myc-DDK (Flag) (5)
Human (9)
Mouse (3)
Rat (1)
293T Cells (2)
HEK 293 Cells (5)
Human Cells (3)
Mammalian Cells (3)
Wheat Germ Extract (2)
Purified (3)
Low endotoxin level (8)
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HEK 293 Cells
Human IgG1 Fc
Less than 0.01 EU/µg protein (determined by LAL method).
~45kDa (SDS-PAGE)
50 µg/$414
TNFRSF18 / GITR Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
24.3 kDa
100 µg/$494
TNFRSF18 / GITR Protein - 12.5% SDS-PAGE of human TNFRSF18 stained with Coomassie Blue
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Wheat Germ Extract
GST
52.4 kDa
10 µg/$479; 25 µg/$670
TNFRSF18 / GITR Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
24.3 kDa
20 µg/$150
TNFRSF18 / GITR Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
26 kDa
20 µg/$150
Select
Mammalian Cells
Fc/6His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
41.12 kDa
10 µg/$277; 50 µg/$389
TNFRSF18 / GITR Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
26 kDa
100 µg/$494
Select
Mammalian Cells
mFc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
41.1 kDa
10 µg/$281; 50 µg/$389
TNFRSF18 / GITR Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
TNFRSF18 / GITR Protein - Purified recombinant protein TNFRSF18 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
23.5 kDa
20 µg/$1,107
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
41.2 kDa
10 µg/$233; 50 µg/$277
Select
HEK 293 Cells
Human IgG1 Fc
Less than 0.01 EU/µg protein (determined by LAL method).
~48kDa (SDS-PAGE)
50 µg/$435
Select
Human Cells
Fc-6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.3kD
10 µg/$277; 50 µg/$395; 500 µg/$1,203; 1 mg/$1,627
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
41.2kD
10 µg/$233; 50 µg/$277; 500 µg/$725; 1 mg/$1,113
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
37.7 kDa
100 µg/$721
Viewing 1-15 of 15 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).