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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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TNFRSF11A / RANK
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11A / RANK is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus.
| Gene Name: | tumor necrosis factor receptor superfamily, member 11a, NFKB activator |
| Family/Subfamily: | TNF Receptor , not assigned-TNF Receptor |
| Synonyms: | TNFRSF11A, CD265, CD265 antigen, ODFR, LOH18CR1, OPTB7, OSTS, PDB2, RANK, Receptor activator of NF-KB, TRANCER, FEO, OFE |
| Target Sequences: | NM_003839 NP_003830.1 Q9Y6Q6 |
Publications (2)
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