TNFRSF10A / DR4

tumor necrosis factor receptor superfamily, member 10a

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4)1. The ligand for this novel death receptor has been identified and termed TRAIL, which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kB activation in many tissues and cells.

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Products

Proteins (6)

Type

Recombinant (6)

Target

TNFRSF10A / DR4 (6)

Publications

No (6)

Tag

6His, C-terminus (1)

Fc (1)

GST, N-terminus (1)

His (1)

Human IgG1 Fc (1)

Species

Human (6)

Source

E. coli (1)

HEK 293 Cells (1)

Human (1)

Human Cells (2)

Wheat Germ Extract (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (5)

Biologically Active

Biologically active (1)

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Human TNFRSF10A / DR4 Protein (Recombinant 6His, C-terminus) - LS-G146151

Source:

Human

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

23.7 kDa

Price:

10 µg/$266; 50 µg/$377

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Human TNFRSF10A / DR4 Protein (Recombinant GST, N-terminus) (aa105-204) - LS-G60869

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TNFRSF10A / DR4 Protein (Recombinant Fc) (Met1-Asn239) - LS-G97959

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

41.3 kDa

Price:

100 µg/$502

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Human TNFRSF10A / DR4 Protein (Recombinant His) (Met1-Asn239) - LS-G98674

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

15.7 kDa

Price:

100 µg/$502

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Human TNFRSF10A / DR4 Protein (Recombinant) - LS-G348

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

22.7 kDa

Price:

10 µg/$268; 50 µg/$349

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Human TNFRSF10A / DR4 Protein (Recombinant Human IgG1 Fc) (aa24-239) - LS-G3908

Source:

HEK 293 Cells

Tag:

Human IgG1 Fc

Endotoxin Level:

Less than 0.01 EU/µg protein (determined by LAL method).

Molecular Weight:

~52kDa (SDS-PAGE)

Price:

50 µg/$337

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