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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
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Additional Contact Details
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TNFAIP6 / TSG-6
tumor necrosis factor, alpha-induced protein 6
TNFAIP6 / TSG-6 is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.
| Gene Name: | tumor necrosis factor, alpha-induced protein 6 |
| Synonyms: | TNFAIP6, Hyaluronate-binding protein, TNF-stimulated gene 6 protein, TSG-6, TNF alpha-induced protein 6, TSG6 |
| Target Sequences: | NM_007115 NP_009046.2 P98066 |
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