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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
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TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.
| Gene Name: | tumor necrosis factor, alpha-induced protein 1 (endothelial) |
| Synonyms: | TNFAIP1, BACURD2, BTBD34, B61, EDP1, Protein B12, B12 |
| Target Sequences: | NM_021137 NP_066960.1 Q13829 |
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