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TMPRSS6

transmembrane protease, serine 6

Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Plays a role in the regulation of iron homeostasis, a process involving HAMP. Required to sense iron deficiency and suppress activation of the HAMP promoter.

Gene Name:	transmembrane protease, serine 6
Family/Subfamily:	Protease , Serine S1
Synonyms:	TMPRSS6, MTSP4, IRIDA, Matriptase-2
Target Sequences:	NM_153609 NP_705837.1 Q8IU80

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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