TMEPAI / PMEPA1

prostate transmembrane protein, androgen induced 1

Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514).

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ELISA Kits (1)

Type

Sandwich (1)

Target

TMEPAI / PMEPA1 (1)

Reactivity

Human (1)

Format

12 x 8-Well Microstrips (1)

Publications

No (1)

Sample Type

Plasma (1)

Serum (1)

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Human TMEPAI / PMEPA1 (Sandwich ELISA) ELISA Kit - LS-F38116

Type:

Sandwich

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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