TMEPAI / PMEPA1

prostate transmembrane protein, androgen induced 1

Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514).

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Products

Antibodies (13)

Type

Primary (13)

Target

TMEPAI / PMEPA1 (13)

Reactivity

Human (13)

Mouse (5)

Rat (4)

Application

IHC (8)

IHC-P (3)

WB (12)

ELISA (6)

IF (6)

Peptide-ELISA (3)

Host

rabbit (13)

Product Group

IHCPlus (1)

Isotype

IgG (11)

Clonality

polyclonal pc (13)

Format

Unconjugated (13)

Epitope

70-150 aa, Internal (1)

Internal (1)

aa101-150 (1)

aa75-124 (1)

Publications

No (13)

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IHC-plus™ TMEPAI / PMEPA1 Antibody (aa101-150) LS-B6326

(4.0) Rating

Antibody:

TMEPAI / PMEPA1 Rabbit anti-Human Polyclonal (aa101-150) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$460

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TMEPAI / PMEPA1 Antibody (Internal) LS-C353493

Antibody:

TMEPAI / PMEPA1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

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TMEPAI / PMEPA1 Antibody (aa75-124) LS-C200502

Antibody:

TMEPAI / PMEPA1 Rabbit anti-Human Polyclonal (aa75-124) Antibody

Reactivity:

Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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TMEPAI / PMEPA1 Antibody LS-C747344

Antibody:

TMEPAI / PMEPA1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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TMEPAI / PMEPA1 Antibody LS-C823133

Antibody:

TMEPAI / PMEPA1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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TMEPAI / PMEPA1 Antibody LS-C754216

Antibody:

TMEPAI / PMEPA1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

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TMEPAI / PMEPA1 Antibody LS-C804582

Antibody:

TMEPAI / PMEPA1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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TMEPAI / PMEPA1 Antibody (70-150 aa, Internal) LS-C385561

Antibody:

TMEPAI / PMEPA1 Rabbit anti-Human Polyclonal (70-150 aa, Internal) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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TMEPAI / PMEPA1 Antibody LS-C358494

Antibody:

TMEPAI / PMEPA1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC-P, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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TMEPAI / PMEPA1 Antibody LS-C779214

Antibody:

TMEPAI / PMEPA1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

TMEPAI / PMEPA1 Antibody LS-C813945

Antibody:

TMEPAI / PMEPA1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

TMEPAI / PMEPA1 Antibody LS-C833795

Antibody:

TMEPAI / PMEPA1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

TMEPAI / PMEPA1 Antibody LS-C769703

Antibody:

TMEPAI / PMEPA1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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