TMEM30A

transmembrane protein 30A

Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF), synthetic drug alkylphospholipid edelfosine, and, probably in association with ATP8B1, of perifosine. Also mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

TMEM30A (4)

Publications

No (4)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human TMEM30A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85971

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.5 kDa

Price:

20 µg/$150

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Human TMEM30A Protein (Recombinant GST) (Full Length) - LS-G34423

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

67.1 kDa

Price:

10 µg/$479; 25 µg/$670

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Human TMEM30A Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69970

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.5 kDa

Price:

20 µg/$1,107

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TMEM30A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G111867

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.5 kDa

Price:

100 µg/$494

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