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TMEM123 / Porimin
transmembrane protein 123
TMEM123 / Porimin is a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death.
| Gene Name: | transmembrane protein 123 |
| Synonyms: | TMEM123, KCT-3, KCT3, PORMIN, Transmembrane protein 123, Porimin, Serine/threonine-rich receptor |
| Target Sequences: | NM_052932 NP_443164.2 Q8N131 |
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