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TMED9
transmembrane emp24 protein transport domain containing 9
Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB.
| Gene Name: | transmembrane emp24 protein transport domain containing 9 |
| Synonyms: | TMED9, gp25L2 protein, Glycoprotein 25L2, gp25L2, HSGP25L2G, p24 family protein alpha-2, p24alpha2, p25, GMP25 |
| Target Sequences: | X90872 CAA62380.1 Q9BVK6 |
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