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TM7SF4 / DC-STAMP
dendrocyte expressed seven transmembrane protein
Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.
| Gene Name: | dendrocyte expressed seven transmembrane protein |
| Synonyms: | DCSTAMP, DC-STAMP, HDC-STAMP, IL-Four (IL-4) induced, IL-four-induced protein, IL-4-induced protein, IL-Four INDuced, TM7SF4, FIND |
| Target Sequences: | NM_030788 NP_110415.1 Q9H295 |
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