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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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TM2D1 / BBP
TM2 domain containing 1
TM2D1 / BBP is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death.
| Gene Name: | TM2 domain containing 1 |
| Synonyms: | TM2D1, Beta-amyloid-binding protein, BBP, TM2 domain containing 1, HBBP |
| Target Sequences: | NM_032027 NP_114416.1 Q9BX74 |
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