TLR4

toll-like receptor 4

Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni2+. Responses triggered by Ni2+ require non-conserved histidines and are, therefore, species-specific. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

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Products

Proteins (16)

Type

Over-Expression Lysate (2)

Recombinant (14)

Target

TLR4 (16)

Application

SDS-PAGE (1)

Publications

No (16)

Tag

10His-SUMO, N-terminus + Myc, C-terminus (1)

6His, N-terminus (1)

GST (1)

GST, N-terminus (2)

His (2)

His, N-Terminal (2)

His,C-terminus (1)

His-S (1)

His-T7, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (11)

Mouse (2)

Rat (2)

Source

293T Cells (1)

Baculovirus (2)

E. coli (6)

HEK 293 Cells (3)

Wheat Germ Extract (3)

Yeast (1)

Purification

Purified (5)

Low Endotoxin Level

Low endotoxin level (3)

Biologically Active

Biologically active (1)

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Mouse TLR4 Protein (Recombinant 6His, N-terminus) (aa26-638) - LS-G57270

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$499; 20 µg/$364; 1 mg/$1,683

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Mouse TLR4 Protein (Recombinant His, N-Terminal) (aa26-269) - LS-G12764

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

33.3 kDa

Price:

10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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Rat TLR4 Protein (Recombinant 10His-SUMO, N-terminus + Myc, C-terminus) (aa26-638) - LS-G56024

Source:

E. coli

Tag:

10His-SUMO, N-terminus + Myc, C-terminus

Price:

100 µg/$1,128; 20 µg/$721

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Human TLR4 Protein (Recombinant GST) (Full Length) - LS-G30722

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

99.7 kDa

Price:

2 µg/$439

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Human TLR4 Protein (Recombinant) - LS-G133796

Source:

HEK 293 Cells

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

69.3 kDa or 90-100 kDa

Price:

10 µg/$268; 50 µg/$349

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Rat TLR4 Protein (Recombinant His, N-Terminal) (His49-Gln247) - LS-G12761

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

28.4 kDa

Price:

10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723

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Human TLR4 Protein (Recombinant His,C-terminus) (Met1-Lys631) - LS-G47438

Source:

Baculovirus

Tag:

His,C-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The secreted recombinant human TLR4 consists of 619 amino acids and predicts a molecular mass of 70.5 kDa. The apparent molecular mass of the protein is approximately 68 kDa in SDS-PAGE under reducing conditions due to glycosylation.

Price:

100 µg/$441; 1 mg/$2,003

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Human TLR4 Protein (Recombinant GST, N-terminus) (aa130-201) - LS-G60373

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TLR4 Protein (Recombinant GST, N-terminus) (aa214-291) - LS-G60374

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TLR4 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68317

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

93.2 kDa

Price:

20 µg/$1,107

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Human TLR4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81918

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

93.2 kDa

Price:

20 µg/$215

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Human TLR4 Protein (Recombinant His-S) (aa326-634) - LS-G12763

Source:

E. coli

Tag:

His-S

Molecular Weight:

41.0 kDa

Price:

10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934

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TLR4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107285

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

93.2 kDa

Price:

100 µg/$710

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Human TLR4 Protein (Recombinant His-T7, N-terminus) (Cys29-Leu253) - LS-G133412

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

29.0kDa

Price:

10 µg/$266; 50 µg/$349; 200 µg/$692; 100 µg/$555; 1 mg/$1,709; 500 µg/$1,286; 5 mg/$2,659; 2 mg/$1,886

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Human TLR4 Protein (Recombinant His) (aa214-291) - LS-G140994

Source:

E. coli

Sequence Length:

77 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

8.58 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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Human TLR4 Protein (Recombinant His) (Met1-Lys631) - LS-G98672

Source:

Baculovirus

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

70.5 kDa

Price:

100 µg/$721

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